Jun 03, 2022

Job Description

100,000 + people across 140 countries are working for Novartis to discover, develop and successfully market innovative products to prevent and cure diseases, to ease suffering, and to enhance the quality of life!

Biotransformation is a key discipline within the Drug Disposition (DD) unit of the Pharmacokinetic (PK) Sciences department that is essential for the progression of small molecules and new modalities such as drug-protein conjugates, oligonucleotides, peptides and radio-ligands from preclinical discovery into human and up to regulatory filing.

PK Sciences is currently seeking a Senior Scientist level, laboratory-based candidate to join the biotransformation team in Cambridge, MA. In this role, you will be joining a large global team of skilled and motivated drug metabolism scientists who closely collaborate with other groups both within and outside of PKS in a highly cross-functional environment.

As the successful candidate you will be adaptable, independently motivated, and challenge driven with a history that demonstrates strong interpersonal skills that encourage successful collaborative working relationships. In this role, you will work in a team environment to support programs through the conduct of drug metabolism studies designed to understand ADME properties, biotransformation pathways, and routes of elimination for a diverse portfolio of therapeutic modalities. Your major responsibilities will include planning, conducting and documenting experiments designed to investigate metabolic pathways and structural elucidation of metabolites formed from new drug candidates. You will also be given many opportunities to diversify your skills and develop your career.

Your main accountabilities will include:
• Design and execution of biotransformation studies to assess metabolic pathways, soft-spot identification, structural elucidation, and bioactivation of drug candidates
• Organize and prepare experimental protocols and study reports with upload of results to a centralized database
• Presentation of key findings to project teams and/or other stakeholders
• Support discovery, pre-clinical, and clinical development studies (in vitro and in vivo) to aid drug candidate progression
• Assure quality standard guidelines and safe work practices are applied while working in the laboratories

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:
• Chemistry/Biochemistry/Biology/Pharmaceutical Sciences degree with experience in drug discovery, or a higher degree with research experience relevant to drug metabolism or mass spectrometry science
• PhD with 0+ years, MS with ≥5 years, or BS with ≥10 years of relevant experience

The ideal candidate will draw from any the following key skillsets:
• Familiarity with in vitro systems (hepatocytes, microsomes, S9 fraction, recombinant enzymes)
• Hands-on experience in operation, maintenance, and troubleshooting of state of the art high resolution UPLC-MS instruments
• Prior experience with either oligonucleotide and/or intact protein analysis is desired but not required
• Excellent oral and written communication skills
• Careful attention to detail, exceptional organizational skills and ability to multitask

Why Novartis?
766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Translational Medicine
Cambridge, MA
Research & Development
Full Time
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Biotransformation Scientist, PK Sciences

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