Jun 27, 2022

Job Description

6000! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

The Biological Engineering and Gene Therapy group at NIBR is working to turn the latest in leading edge gene therapy and nucleic acid science into treatments. In this opportunity, you will advance nucleic acid and gene editing therapies such as siRNA and AAV. Join us today if you are passionate about analytics and want to apply your skills to the gene editing / nucleic acid fields.

Your responsibilities: (may include, but are not limited to)
• Provide characterization and quantitative analytics expertise to support projects from exploratory characterization through NHP studies.
• Develop and execute LC-MS and other assays to support therapeutic oligonucleotide platforms.
• Evaluate and apply a variety of analytical methods for biological, chemical and physical characterization of therapeutic oligonucleotides.
• Write experimental protocols, internal reports and present results at meetings.
• Study the biodistribution, PK, stability and tissue targeting of siRNA and oligo therapeutics.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you’ll bring to the role:
• BA/BS and 3+ years or MS and 1+ years of meaningful experience in analytical chemistry, molecular biology or a related field.
• Significant experience with assay development/optimization particularly HPLC methods using various detectors, LC-MS, and LC-MS/MS analysis.
• Operational expertise with LC-MS software, the spectral deconvolution of large molecules and/or experience with MS/MS sequencing of proteins/peptides or DNA.
• Solid skills in troubleshooting HPLC and LC-MS systems.
• Experience with common techniques for quantifying and characterizing proteins or DNA such as electrophoresis, spectroscopy, and ELISA.

• Familiarity with cell-based assays and solid phase extraction.

What Novartis can offer you?
Yes, we offer outstanding benefits and competitive salaries. However, we can offer more. Here you will:
• Be part of a team that is advancing gene therapy and RNA therapeutics.
• Gain experience with a variety of gene editing and nucleic acid technologies (AAV, mRNA, siRNA, CRISPR).
• Work with the latest technologies and instrumentation.
• Be part of a world class organization dedicated to providing solutions to un-met medical needs
• Join an organization that is committed to your development and advancement

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Why Novartis?
766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!
Accessibility and Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other
Cambridge, MA
Research & Development
Full Time
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Research Scientist, Mass Spectrometry (BS/MS)

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