May 24, 2022

Job Description

Principal Scientist to Associate Director, Translational Modeling & Simulation (neuroscience)

6000! That is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

The PK Sciences / Translational Modeling & Simulation group is embedded within Translational Medicine, the clinical research arm of NIBR. Our main objective is to enable quantitative approaches to rigorous decision making from target identification to first-in-human studies and beyond. Novartis has a broad pipeline of therapies for psychiatric and neurodegenerative diseases that spans low molecular weight compounds (small molecule), biologics, oligonucleotides, and gene therapies. We are seeking a curious and proactive modeler to apply computational methods to drive the design, characterization, and delivery of these new therapies. Our group is growing, and we hope you will join us as we use computational modeling to generate new insights with both forward and reverse translational approaches.

Your responsibilities will include, but are not limited to:
• Act as the Translational M&S representative on several neuroscience programs by developing and executing modeling strategies, collaboratively contributing to project team discussions, and guiding decisions such as therapeutic design and dose selection.
• Build and apply quantitative systems pharmacology (QSP) models that link drug pharmacology, mechanism(s) of action, and biological outcomes. This will include application of physiologically based PK (PBPK) modeling to better understand the biodistribution of therapeutics in the brain and how this affects safety and efficacy.
• Contribute to the development of integrated modeling platforms for oligonucleotide and AAV gene therapies that bridge data and knowledge from preclinical species to patients, partnering with discovery project teams and with preclinical safety and pharmacometrics groups.
• Contribute to programs across therapeutic modalities and disease indications, as needed. Novartis has a broad portfolio with hundreds of drug discovery and clinical development projects and you will have opportunities to grow and develop as you apply modeling insights to projects beyond neuroscience programs.
• Proactively seek opportunities to increase the impact and awareness of translational modeling through communications with internal and external audiences.
• A modeler at the Sr. Principal Scientist or Associate Director level will have additional strategic responsibilities within the group and will also have opportunities to serve as an M&S subject area expert across PK Sciences and NIBR initiatives.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:
• Ph.D. in biology, pharmacology, bioengineering, biophysics, or a related field. Candidates with backgrounds in mathematics or other quantitative fields with a deep understanding of biological concepts or a master’s degree with 4+ years of industry experience will be considered.
• Prior experience in quantitative systems pharmacology (QSP), pharmacokinetics and pharmacodynamics (PKPD), and/or physiologically based PK (PBPK) modeling is strongly preferred. Expertise with discovery-stage PK modeling for small molecule compounds is a plus (e.g., relating ADME properties to in vivo PK; scaling of preclinical PK to human).
• Understanding of neurobiology and prior experience with the modeling of neuroscience therapeutics is preferred.
• Expert level proficiency in core modeling fundamentals is required, including scripting languages (e.g., MATLAB, R), construction of ordinary differential equation (ODE) models, parameter estimation, and data visualization.
• Demonstrated ability to communicate modeling results to a multidisciplinary audience for collaborative work and/or to facilitate strategy and decision-making.
• Fluent in English (oral and written).
• This is a dual posting. The final level & title of the offered role will be determined by the hiring team based on the skills, experience, and capabilities required to perform the role. A recent graduate or postdoctoral scholar will be considered for the Principal Scientist I level, while more experienced candidates with demonstrated impact as a modeler in the pharmaceutical/biotech industry may be considered for the PS II level. A Senior Principal Scientist / Associate Director will be expected to have extensive industry experience with demonstrated impact via both modeling execution and strategic initiatives.

There are two positions available, and candidates can be considered for both (345276BR).

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network

Why Novartis?
766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!
Translational Medicine
Cambridge, MA
Research & Development
Full Time
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Principal Scientist to Associate Director, Translational M&S

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