Oct 28, 2022

Job Description

85% of the proteome is currently undrugged. Join our effort to tackle a longstanding challenge in early drug discovery by identifying covalent small molecules that modulate the activity of these so far undrugged targets and pathways to positively impact human health.

The Chemical Biology and Therapeutics department is seeking a highly motivated and adaptable candidate for a Scientist position to expand its current effort in chemical proteomics and covalent drug discovery.

Hands-on experience with protein/peptide analysis and quantitative mass spectrometry methods (i.e., TMT, label-free) is required. Familiarity with chemical proteomics and affinity enrichment methodologies, concepts governing compound binding affinity and reactivity, kinetics, and selectivity as well as proficiency in protein biochemistry techniques (liquid chromatography, SDS-PAGE, western blotting, immunoprecipitation, etc.) are highly desired.

The successful candidate will have demonstrated abilities to grow in the field by adoption of new techniques and troubleshooting experimental approaches in an independent fashion. The position requires effective self-management and thriving in a multitasking environment with at times rapidly changing project parameters. Applicants should have good organizational, team and communication skills, and should be able to interpret and present results and scientific information critically and objectively.

Your primary responsibilities:

• Tissue culture
• Chemoproteomic affinity enrichments and sample preparation
• Operation of state-of-the art mass spectrometry and associated equipment
• Analysis of quantitative proteomics data using equipment vendor and 3rd party software
• Immunoassays, biophysical characterization, and flow cytometry
• Report generation and presentation of results and interpretations

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:

Education: B.S., M.S., or Ph.D. in the life sciences or related field with a minimum of 3 years of relevant experience.
• Familiarity with standard proteomic laboratory techniques and practices
• Demonstrated ability to analyze, interpret, and summarize results independently
• Hands on experience in quantitative proteomic workflows used to identify and quantitate biomolecules
• Additional experience with protein/peptide chemical labeling and/or molecular biology techniques is considered a plus

Why consider Novartis?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.

While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions. Please send accommodation requests to [email protected].
San Diego, CA
Research & Development
Full Time
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(Chemo)proteomics Scientist – Biochemistry & analytics NIBR San Diego

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