Oct 28, 2022

Job Description

85% of the proteome is currently undrugged. Join our effort to tackle a longstanding challenge in early drug discovery by identifying covalent small molecules that modulate the activity of these so far undrugged targets and pathways to positively impact human health.

In expansion of our global effort in covalent drug discovery, we are currently looking for a Principal Scientist to drive chemoproteomic efforts at our San Diego site.

Your responsibilities:

The successful candidate will utilize covalent probes to capture protein-ligand interactions and develop novel mass spectrometry-based chemoproteomic strategies to enable covalent library screening as well as rapid follow-up of screening hits using a variety of primarily mass spectrometry-based approaches.

As a member of highly multidisciplinary project teams focusing on early-stage drug discovery and covalency-enabled exploration of new modalities, the position offers considerable opportunities to branch out into other areas of drug discovery including probe design and target validation in vitro and in cells.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:
-Candidates should have a Ph.D. in Chemistry, Biochemistry or Biological Science with at least 5 years of post-graduate research experience.
-The ideal candidate would have a background in mass spectrometry-based proteomics and chemical biology as well as experience in identification of target/ligand pairs in cells.
-Extensive hands-on experience with nanoLC-MS/MS instrumentation, quantitative proteomics approaches (e.g. TMT, label-free) and data analysis is required.
-The individual should be a natural collaborator with strong communication skills and experience contributing to multidisciplinary teams, as well as the ability to be a self-starter and thrive in a multitasking environment.

-Molecular biology skills would be beneficial.
-Practical knowledge in biochemistry and the application of affinity- and activity-based chemical probes for cellular enrichment studies is desired.

Why consider Novartis?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.

While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions. Please send accommodation requests to [email protected].
San Diego, CA
Research & Development
Full Time
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Principal Scientist (Chemo)proteomics & Mass Spec NIBR San Diego

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