May 06, 2022

Job Description

4 FDA approved drugs; 15+ clinical candidates; 400+ patents; 20 years of Novartis Institutes for Biomedical Research - San Diego (NIBR - SD) history! For over 21 years, NIBR - SD has been doing cutting-edge innovative drug discovery for the Novartis global research organization.

The candidate will join a dynamic team involved in the design and synthesis of oligonucleotides for Novartis’s drug discovery programs. This individual will be responsible for the independent operation and maintenance of instruments to synthesize, purify, and analyze chemically modified oligonucleotides for in vitro and in vivo studies. Successful candidates have experience with modern laboratory equipment and spectroscopic analysis, preferably in relation to oligonucleotides, and ability to work on multiple projects in multi-disciplinary team settings. The ideal candidate is a personable and organized team player who thrives in a fast-paced environment. This role provides you with the opportunity to take on increasing responsibility over time within Novartis Global Discovery Chemistry.

Primary Responsibilities:
• Collaborate with scientists throughout the organization on the discovery and advancement of innovative oligonucleotide therapeutics
• Operate oligonucleotide synthesizers, HPLC, and LC-MS for synthesis, qualitative analysis, and purification of synthetic oligonucleotides to produce high quality oligonucleotides for research and drug development programs
• Critical analysis and evaluation of data to optimize synthesis yield, purity, and formulation of modified oligonucleotides
• Quantitate compounds spectroscopically for in vitro and in vivo experiments
• Develop quality control mechanisms and monitoring systems as well as maintain the equipment to ensure consistent and reliable production of oligonucleotides with minimal down time
• Manage procurement and inventory of chemicals and supplies for oligonucleotide synthesis
• Curate and maintain the inventory of synthesized oligonucleotides


Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

• Bachelor’s degree in Chemistry or related scientific discipline with 7 plus years of relevant work experience -OR- a master’s degree in Chemistry or related scientific discipline with 4 plus years of relevant work experience
• One year of experience with operating oligonucleotide synthesis equipment, LC-MS, and HPLC
• A commitment to scientific integrity and laboratory excellence as well as ability to independently interrogate scientific problems and deliver creative solutions
• Strong organizational and record keeping skills
• Knowledge and curiosity in synthetic organic chemistry
• Automation experience to streamline repetitive tasks is a plus

Why Novartis?
799 million. That’s how many lives our products touch. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.
Global Discovery Chemistry
San Diego, CA
Research & Development
Full Time
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Scientist - Oligonucleotide Chemistry

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