Oct 28, 2022

Job Description

Do you want to be part of a team that brings together drug discovery, innovation, and cell and gene therapy expertise to help patients? The Novartis Institutes for Biomedical Research (NIBR), as the innovation engine of Novartis, focuses on translating early drug discovery projects into innovative medicine. The hematology team at NIBR’s Regenerative Medicine research group in La Jolla is looking for a highly motivated senior scientist to join a team developing innovative, transformative in vivo therapies for Sickle Cell Disease and other hematological disorders. There will be a strong emphasis on the application of novel delivery approaches, and development and application of genome engineering technologies.

Your responsibilities include, but are not limited to:

• A crucial role in the development of novel therapeutic concepts and will contribute at all stages of a project, from inception, early project validation, optimization, candidate selection and through early clinical development of novel medicines for patients with hematopoietic disorders
• Culturing stem cell lines and establishing in vitro assays for hematopoietic stem and progenitor cells from human and mouse primary sources
• Introducing constructs to modify/engineer stem cells and stem cell lines
• Independently designing, executing, and interpreting experiments
• Collaborating with in vivo pharmacology teams on xenograft and ex vivo studies according to IACUC and NIBR guidelines
• Coordinating and collaborating with other Novartis departments, external academic and business partners, and CROs to conduct research studies

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you’ll bring to the role:

• Accountability from experimental design, and execution, to data analysis
• Creative problem-solving skills; excellent analytical, communication, and organizational skills.
• Proficiency in culturing primary and stem cells, transfection and transduction methods, molecular biology, molecular cloning, sequence and protein analysis, real-time PCR.
• Proficiency in multi-parameter flow cytometric analysis
• Experience in using gene delivery methods (viral and non-viral) is preferred
• Knowledge in stem cell biology, hematology, and immunology is preferred

Desirable requirements:

• MSc or BSc in a scientific discipline, such as cellular or molecular biology, genetics, or pharmacology, with relevant years of experience in drug discovery or related lab research
• Experience in a laboratory focused on hematopoietic stem cells or other stem cell experimentation
• Enthusiasm to learn and work in a fast-paced, interdisciplinary, collaborative research environment

799 million. That’s how many lives our products touched since 2019. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

Imagine what you could do at Novartis! We are Novartis. Join us and help reimagine medicine.

While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions. Please send accommodation requests to [email protected].
Regenerative Medicine - NIBR
San Diego, CA
Research & Development
Full Time
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Research Scientist (Sr. Scientist) in Hematology and Stem Cell Biology

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