Apr 22, 2022

Job Description

$9.0 billion R&D spend to develop breakthrough medicines! We are seeking a highly motivated scientist to join our In Vivo Pharmacology team in the Cardiovascular and Metabolism (CVM) Disease Area at the Novartis Institutes for BioMedical Research (NIBR) located in Cambridge, MA. Cardiovascular disease is the leading cause of death worldwide, taking an estimated 17.9 million lives each year. Our team is dedicated to the creation and development of innovative medicines to change this alarming statistic. We conceive, develop, validate and employ pharmacological tools to evaluate the efficacy and safety of novel cardiovascular drug candidates.

As an In Vivo Pharmacologist, you will work independently and collaboratively in an inter-disciplinary setting to design and execute experiments in preclinical models, analyze/interpret data, write study reports and give oral presentations. You will drive drug discovery for therapies targeting atherosclerosis, while also having the opportunity to broaden your knowledge of other therapeutic areas within CVM (e.g. heart failure, arrhythmia, and metabolism).

Key Responsibilities:
• Establish in vivo and ex vivo models of atherosclerosis progression and/or regression
• Establish in vivo and ex vivo tools (e.g. methods to determine macrophage phenotype, function and trafficking) required to define the impact of potential therapeutics on plaque composition and function
• Design, execute, analyze and document in vivo and ex vivo experiments
• Perform biochemical and/or histological analyses on samples
• Identify targets to pursue in collaboration with colleagues, and progress targets forward toward therapeutics
• With time and experience, lead one or more drug development projects in the field of atherosclerosis from target concept to IND-enabling studies
• Recognize and leverage external collaboration opportunities that amplify the department’s research
• Present results in lab, team and department meetings
• Independently compose research reports to support regulatory filings

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:
• PhD in pharmacology, biochemistry, cell biology, or other life science area; post-doctoral training (>2 years) is preferred
• Subject expertise in the biological function of plaque macrophages during atherosclerosis progression and/or regression is desired
• Competence with the in vivo and ex vivo tools (e.g. methods to determine macrophage phenotype, function and trafficking) required to define the impact of potential therapeutics on plaque composition and function is also desired
• Hands-on experience with collection and processing of murine atherosclerotic plaques for histology is a plus
• Capacity to quickly grasp new concepts, findings and techniques
• Basic computational data analysis skills and experience with commonly used statistical software for biomedical research
• Proficiency with Microsoft Office (Word, Excel and PowerPoint)
• Excellent written, communication and organizational skills

769 million. That’s how many lives our products touch. At Novartis, being there when and how it matters most for our patients and customers allows us to live our purpose and help bring maximum impact to health outcomes.

Furthering our commitment to transforming medicine for patients, Novartis is embarking on an ambitious and exciting journey to reinvent how we use technology, data and customer insights to better serve our consumer’s needs and put them on a path to better health. This includes taking bold approaches that begin with a customer-centric mindset and harness the power of today’s digital and data-driven healthcare revolution to continue to improve and extend even more people’s lives.

• Do you want to help people understand their disease and how to seek out the proper treatment for it?
• Do you want to support patients achieve the best possible outcomes?
• Do you want to deliver a leading customer experience at all touchpoints?
• Do you want to be at the forefront of leveraging today’s technology advances to create tomorrow’s healthcare innovations?

We believe the answers are found when curious, adventurous, and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to utilize the power of digital and data to individualize and maximize interactions with customers. Where you’re empowered to not fear failure when taking smart risks. And most importantly, where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.

Join our Novartis Network:
If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
CVM Disease Area
Cambridge, MA
Research & Development
Full Time
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Principal Scientist I, In Vivo Pharmacology (CVM)

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