Apr 28, 2022

Job Description

450! that’s the number of projects we touch in PK Sciences from discovery through development across all disease areas and therapeutic modalities.

PK Sciences (PKS) is a global organization of about 300 associates, situated within Translational Medicine (TM), the clinical research arm of NIBR. PKS plays a pivotal role in bringing innovative medicines to patients, by building on research advances to develop new therapies, bridging drug discovery and clinical application.

PKS is an enterprise organization, working across both NIBR and the Global Drug Development organizations to advance the scientific knowledge of pharmacokinetics/pharmacodynamics, metabolism, and clinical pharmacology from discovery through approval and beyond.

Modeling and Simulation (M&S) is a key function within PK Sciences. We impact projects from drug design to submission using innovative modeling techniques like translational modeling (e.g., quantitative systems pharmacology; QSP), data science, biophysical modeling, and physiologically-based PK modeling (PBPK).

As Director Translational Modeling and Simulation, you will lead one of our global teams in Basel. We are looking for an innovator who will help us to integrate Data Science, PBPK and QSP to impact projects from Discovery to First-in-Human by anticipating human PK/PD as early as possible.

You are an accomplished leader who will create impact across the pipeline with innovative modeling approaches. You will mentor and grow our team members. In addition, this position will take on the role of M&S site head in Basel. As M&S site head, you will strengthen our global team and foster collaboration between our different modeling groups located in Basel. You will be the interface with local leaders within PKS, Translational Medicine and beyond.

Your main accountabilities will include but are not limited to:
• As the M&S site head in Basel, member of the global M&S leadership team, and member of the TM data science extended leadership team, you will have a visible role in connecting innovative modeling solutions to the discovery and development portfolios.
• Closely collaborate with the other Translational M&S team leads to build the culture and capabilities of the global group, further establishing and growing the team as a center of excellence for QSP / translational modeling.
• Oversee Translational M&S needs in the autoimmune and musculoskeletal disease areas and Basel-based projects from other disease areas. This includes prioritization of M&S resources and stakeholder engagement as well as the generation of platform and disease models that span projects.
• Provide thoughtful and personalized leadership to your direct reports and to others within M&S. Translational M&S is a dynamic field with representation across STEM fields and multidisciplinary collaborations, mentorship, and training are essential.

Diversity & Inclusion / EEO

Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Minimum Requirements

What you will bring to the role:
• A doctorate degree (Ph.D. or equivalent) in a relevant STEM field.
• 10+ years in applying QSP modeling to drug discovery and development, with an exemplary track record in the mechanistic understanding of drug design, drug pharmacology (PK/PD-efficacy), and target & disease biology.
• Curious and inspired problem solver with demonstrated experience leading translational M&S activities that positively impacted drug discovery and/or development programs. Experience integrating M&S with other quantitative disciplines such as data science, clinical PBPK, and/or clinical pharmacometrics is highly preferred.
• Innovative, passionate leader who displays high emotional intelligence and strong people leadership skills to enable a high performing team and sustainable collaborations across the organization.
• Demonstrates ability to lead in a matrix organization across PK Sciences, Translational Medicine, and NIBR.

Why Novartis?

769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

Join our Novartis Network:

If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Translational Medicine
Research & Development
Full Time
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Director - Translational (QSP) Modeling & Simulation

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