Jun 24, 2022

Job Description

4 FDA approved drugs; 15+ clinical candidates; 400+ patents; 21 years of NIBR - San Diego history!

The Antibody and Bioconjugates Discovery group at NIBR - La Jolla, is seeking an expert antibody and protein engineer to lead discovery and optimization efforts. The successful Senior/Principal Scientist candidate will join a highly collaborative group of protein scientists and antibody drug hunters devoted to discovering novel biotherapeutics to impact a wide range of human diseases.

Your responsibilities:
• Apply expertise in biochemistry and molecular biology to optimize antibodies for diverse therapeutic approaches using structure-guided and classic engineering approaches
• Lead a sub-group of scientists to execute antibody optimization platform efforts such as humanization, affinity maturation, and specificity modulation
• Generate, implement, and prioritize innovative ideas, recognize risks and propose mitigation or contingency plans
• Maintain knowledge of internal and external advances in the areas of expertise
• Communicate effectively with diverse project teams and other core groups within NIBR to effectively advance molecules toward clinical trials

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:
• PhD in biochemistry, chemical biology, molecular biology or related discipline with post-doc, or equivalent, 5+ years of industry experience
• Extensive knowledge and hands-on experience in yeast display library design, generation, and screening for antibody optimization
• Ability to independently synthesize project information into experimental designs, and to strategically apply resources to solve challenges
• Experience leading and developing talent, creativity, excellent communication skills, and a history of accountability to quality outputs

Highly desirable:
• Experience in an industry antibody therapeutics group or exposure to immunization and display based antibody discovery
• Understanding of and/or hands-on experience with any of the following: next-generation sequencing, computational structure-based protein design using state of the art tools (e.g. Rosetta, Schrodinger, MOE, Molsoft), bispecific antibody screening, and antibody fragments ats engineering (scfv’s, single domain antibodies, bioconjugates)
• Experience in molecular biology techniques for library generation or high throughput cloning

Why consider Novartis?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you are given opportunities to explore the power of digital and data. Where you are empowered to risk failure by taking smart risks, and where people who share your determination to tackle the world’s toughest medical challenges surround you.

We are Novartis. Join us and help us reimagine medicine!
San Diego, CA
Research & Development
Full Time
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Principal Scientist Antibody & Bioconjugates Discovery NIBR La Jolla

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