Apr 08, 2022

Job Description

Sickle cell disease (SCD) is the most common genetic hematological disorder, accounting for over 305,000 births in 2010, with millions of people affected across the globe centralizing in low and middle income countries. The condition can cause extreme pain, life-threatening infections and other complications such as stroke or loss of vision. The disease can drastically impact the quality of life of inflicted individuals. While the standard of care is treatment of symptoms, we are pursuing gene therapy as a potential cure for sickle cell disease (SCD). As the innovation engine of Novartis, the Novartis Institutes for Biomedical Research (NIBR) is collaborating with the Bill and Melinda Gates Foundation to develop in vivo gene therapies for SCD.

Do you want to be part of a team that brings together NIBR drug discovery, innovation, and gene therapy expertise with funding support from the Gates foundation; focusing on early drug discovery projects that translate into medical revolution for Sickle Cell Disease?

The Immuno-Oncology and Hematology (IOH) department at NIBR is looking for a highly motivated scientist\\newly graduated PhD candidate to join a team developing innovative, transformative in vivo therapies for Sickle Cell Disease. IOH is a highly dynamic and collaborative research department that interfaces innovative biology, genetic engineering, viral and non-viral delivery platforms, and genome analysis for pre-clinical drug development and translational medicine:

Your responsibilities include, but are not limited to:

•A crucial role in the development of novel therapeutic concepts and will contribute at all stages of a project, from inception, early project validation, optimization, candidate selection and through early clinical development of novel medicines for patients with sickle cell disease
•Culturing cell lines and establishing in vitro assays for hematopoietic stem and progenitor cells from human and mouse primary sources
•Independently designing, executing, and interpreting experiments
•Executing in vivo pharmacology studies according to IACUC and NIBR guidelines
•Coordinating and collaborating with other Novartis departments, external academic and business partners, and CROs to conduct research studies
•Maintaining detailed documentation of experiments in the NIBR electronic system

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you’ll bring to the role:

•Accountability from experimental design, and execution, to data analysis
•Creative problem-solving skills; excellent analytical, communication, and organizational skills.
•Ability to perform mouse procedures and injections (SC, IP, IV, RO), monitor animal health biometrics, and harvest tissues
•Experience in mouse bleeding and bone marrow isolation procedures
•Proficiency in cell and molecular biology, molecular cloning, sequence and protein analysis, real-time PCR, cell culturing, transfection and transduction methods
•Proficiency in multi-parameter flow cytometric and NGS analysis
•Deep understanding of gene editing tools and principles.
•Knowledge in stem cell biology, hematology, and immunology is preferred

Preferred requirements:

•MS in a scientific discipline, such as cell or molecular biology, genetics, or pharmacology, with relevant years of experience in drug discovery or related lab research, or PhD with relevant research experience
•Experience in gene editing
•Experience in using gene delivery methods (viral and non-viral)
•Experience in a laboratory focused on hematopoietic stem cells
•Enthusiasm to learn and work in a fast-paced, interdisciplinary, collaborative research environment

Why consider Novartis?

766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

What Novartis can offer you?

Yes, we offer exceptional benefits and competitive salaries. However, we can offer more. Here you will:

• Get access to latest technologies and work with talented scientists
• Virtually learn and earn certificates from 190 universities around the world, all supported by Novartis through our partner Coursera.
• Get access to the Novartis Learning Institute which offers personal effectiveness, digital capability and language programs, as well as talent acceleration and leadership programs.

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse team representative of the patients and communities we serve.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Cambridge, MA
Research & Development
Full Time
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Research Scientist – Sickle Cell Disease; Hematology

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