Apr 08, 2022

Job Description

Over 35 preclinical targets in our pipeline! NIBR Oncology strives to reimagine medicines for cancer patients through a combination of treatment approaches including antibody-drug conjugates, targeted protein degraders, and radioligand therapeutics. The Novartis Oncology Biotherapeutics Group is dedicated to the discovery and development of next generation biologics and is employing first-in-class approaches for the treatment of solid tumors and hematological cancers.

We are seeking a BS/MS Research Scientist, Oncology Biotherapeutics who is highly motivated, innovative, collaborative and results-driven for the Novartis Oncology Biotherapeutics group in Cambridge, MA. You will work on multiple programs at various stages of early drug discovery research, including the ideation, discovery, and optimization of antibody therapeutics for the clinic. In this role, you will have the opportunity to independently screen and characterize drug candidates with advanced cell-based assays. The successful candidate will be a critical contributor in a dynamic and multidisciplinary group, with opportunities to interact with other functional groups, to understand the process of preclinical discovery of oncology drugs, and finally to transform the lives of cancer patients.

The candidate will be working towards exploring the biology of emerging drug targets, testing exciting novel biologics, and studying their mechanism of action with the aim of eventually delivering drug candidates for evaluation in clinical trials.

Key responsibility:
• Perform cell-based assays to screen potent cell engaging antibodies and other biologics formats
• Carry out cell-based experiments to characterize drug candidates to support regulatory filing for first-in-human clinical trials. Techniques used will include but are not limited to: flow cytometry, cell sorting, cell culture, HTRF/ELISA immunoassays, luminescent-based cell assays, Western blotting, and CRISPR technologies
• Use of automation and high-throughput systems to support large scale drug screening
• Explore the biology of emerging drug targets or exciting novel formats of biologics
• Design and implement experiments with input from team members and experts; troubleshoot technical issues; analyze and interpret the data; formulate hypotheses and design follow-up experiments
• Document results in a detailed manner in laboratory journal and internal databases
• Present research updates and participate constructively in project team meetings and at laboratory group meetings

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

• MS or BS with at least 2 years of prior experience in academia or industry in cell biology, cancer biology, oncology drug discovery or antibody therapeutics.
• Hands-on expertise in cell culture, in vitro cell assays, transient/stable cell line generation, and flow cytometry.
• Capable of documenting experiments, analyzing and interpreting data, and communicating results within a team environment.
• Excellent technical skills, time management, and lab citizenship. A collaborative teammate mind-set is crucial.

Desirable qualifications:
• Experience with or passion to learn high-throughput instruments is highly desired.
• Prior experience with antibodies or biologics is preferred.
• Experience with luminescent-based cell assays, including but not limited to bioluminescence resonance energy transfer based assays and bioluminescent protein quantification assays.

Accessibility and reasonable accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.


Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.
Oncology NIBR
Cambridge, MA
Research & Development
Full Time
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BS / MS Scientist, Oncology Biotherapeutics

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