342694BR
Apr 15, 2022
Switzerland

Job Description

PKS- Drug Disposition - Global Biotransformation – Regulatory Metabolite Identification and Outsourcing Excellence

Do you want to be at the forefront of the fight against multiple diseases making an impactful contribution in bringing transformative therapies to patients and be part of Novartis’ mission to reimagine medicine to improve and extend people’s lives?

The department of PK Sciences (PKS) offers you this unique opportunity to make an impact where 450 projects are straddling discovery through development. PKS is a global organization of about 300 associates, within the Translational Medicine (TM) department, in Novartis Institutes of Biomedical Research (NIBR). PKS is dedicated to collaborating across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. PKS is currently seeking a Scientist, laboratory-based candidate to join the biotransformation team in Basel, Switzerland. The candidate will be joining a large global team of skilled and motivated drug metabolism scientists who closely collaborate with other groups both within and outside of PKS in a highly cross-functional environment.
The successful candidate is adaptable, highly motivated and challenge driven with a history that demonstrates strong interpersonal skills that encourage successful collaborative working relationships. In this role, you will work in a team environment to support programs through the conduct of drug metabolism studies designed to understand biotransformation pathways and routes of elimination of diverse therapeutic modalities. Major responsibilities include planning, conducting and documenting experiments designed to investigate metabolic pathways and structural elucidation of metabolites formed from new drug candidates. The candidate will also be given many opportunities to pursue skill diversification for career development.
Responsibilities:
• Design and execution of biotransformation studies to assess metabolic pathways, structural elucidation, and bioactivation of drug candidates
• Organize and prepare experimental protocols and study reports with upload of results to a centralized database
• Develop and perform assays to characterize the metabolism of small molecule as well as new modalities
• Support pre-clinical, and clinical development ADME studies (in vitro and in vivo) to aid drug candidate progression
• Assure quality standard guidelines and safe work practices are applied while working in the laboratories

Diversity & Inclusion / EEO

Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Minimum Requirements

The ideal candidate will draw from any the following key skillsets:
• Familiarity with in vitro systems (hepatocytes, microsomes, S9 fraction, recombinant enzymes) and in vivo bioanalyses
• Hands-on experience in operation, maintenance, and troubleshooting of state of the art high resolution UPLC-MS instruments
• Knowledge of safe handling practices and tracking of samples including radioactivity would be a plus
• Familiarity with mass spectrometer data interpretation for small molecule and or proteins
• Prior experience with radiolabeled compounds would be an asset
• Experience with radioactivity detection TopCount, Liquid Scintillation Counting (LSC) and Accelerated Mass Spectrometry (AMS) would be beneficial
• High interest in evaluating and implementing new technologies (Ion Mobility, LESA, MALDI etc.)
• Excellent oral and written communication skills
• Careful attention to detail, exceptional organizational skills and ability to multitask
• Strong and highly supportive team player, with aim to work in a highly collaborative environment

Basic Qualifications:
• Degree in Chemistry/Biochemistry/Biology/Pharmacology with research experience relevant to drug metabolism science
• MSc with ≥3 years, or BSc with ≥7 years of relevant experience

Why Novartis?
766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse,
equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we
collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!
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NIBR
Translational Medicine
Switzerland
Basel
Research & Development
Full Time
Regular
No
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342694BR

Research Scientist (PK Sciences)

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