Mar 15, 2022

Job Description

6000! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

We are seeking a highly motivated, collaborative and curious Principal Scientist to lead the Lentivirus and Hematopoietic Stem Cell (LV-HSC) Engineering Team within NIBR’s Immuno-Oncology & Hematology (IOH) Research Department.

We are dedicated to innovating the next generation of ex vivo engineered HSC therapies for genetic diseases that can be treated with HSC transplantation.

As a leader of a dynamic, multidisciplinary team, you will lead the design, production and characterization of novel lentiviral vectors for therapeutic use. IOH is a highly dynamic and collaborative drug discovery department that interfaces innovative biology, genome analysis, genetic engineering, gene and cell therapy platforms (including CAR-T therapeutics) with pre-clinical development and translational medicine. The discoveries we make can contribute directly to improving efficacy and accessibility of gene therapies to patients.

Your responsibilities include, but are not limited to:

•You will assume a crucial role in the development of novel therapeutic concepts and will contribute at all stages of a project, from inception, early project validation, optimization, candidate selection and through to early clinical development of novel engineered HSC therapies with a primary focus on designs of lentiviral vectors for clinical use.
•You will work collaboratively with other experts to develop project strategy, identify key drug discovery issues, propose and implement creative solutions, execute and guide teams to success and decision points.
•You will lead the design of novel lentiviral vectors for therapeutic use leveraging expertise in HIV biology and molecular virology.
•You will manage a team of associates.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you’ll bring to the role:

•Ph.D. (or MD/Ph.D.) with 3 to 5 years experience in biological sciences such as virology, molecular biology, cell biology, biochemistry or immunology, with several international publications. Preference to candidates with experience with HIV.
•The candidate will have a demonstrable record of accomplishment of driving and supporting multiple research projects, and contributions as an author to high-impact, peer-reviewed publications in the field.
•Self-motivation, ability to work independently, passion for working in an interdisciplinary, collaborative research environment.
•Will possess excellent oral and written communication skills and an ability to thrive in a dynamic matrix research environment.
•Creative problem-solving skills; excellent analytical, communication and organizational skills.

Desirable requirements:

•Preference given to candidates with experience in gene therapy and/or lentiviral vectors.
•Experience with HSC biology preferred.

Why consider Novartis?

766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

What Novartis can offer you?

Yes, we offer exceptional benefits and competitive salaries. However, we can offer more.

Here you will:

• Get access to latest technologies and work with talented scientists
• Virtually learn and earn certificates from 190 universities around the world, all supported by Novartis through our partner Coursera.
• Get access to the Novartis Learning Institute which offers personal effectiveness, digital capability and language programs, as well as talent acceleration and leadership programs.

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse team representative of the patients and communities we serve.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Cambridge, MA
Research & Development
Full Time
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Principal Scientist - Lentivirus and HSC Engineering

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