Mar 15, 2022

Job Description

6000! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

We are seeking a highly motivated, collaborative, and curious Senior Scientist to join the Lentivirus and Hematopoietic Stem Cell (HSC) Engineering Team within NIBR’s Immuno-Oncology & Hematology (IOH) Research Department.

We are dedicated to innovating the next generation of ex vivo engineered HSC therapies for genetic disease, that can be treated with HSC transplantation. The discoveries we make can contribute directly to improving efficacy and accessibility of gene therapies to patients.

As a key contributor in a dynamic, multidisciplinary team, you will be involved in the design, production, efficacy and safety of novel lentiviral vectors for therapeutic use.

Your responsibilities include, but are not limited to:

•Conduct and optimize experiments independently; record, interpret, and communicate data promptly;
•Contribute to viral design, production and analysis activities at research scale;
•Perform ddPCR, flow cytometry and western blot analysis to assess virus quality, virus transduction efficiency and expression of gene therapy products;
•Establish and perform in vitro cell based assays to support gene therapy research;
•Present data in meetings and contribute to discussion;
•Maintain and organize reagents and stock solutions.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you’ll bring to the role:

•BS with 5+ years or MS degree with 3+ year in virology, cell biology, molecular biology, or biology with a minimum of 5 -8 years of relevant research experience in industry or academic lab. Level will be commensurate with relevant experience.
•Experience with molecular biology and cloning for the design and production of novel therapeutic cargos for lentiviral vector production
•Experience with mammalian cell culture
•Experience carrying out in vitro assays using molecular biology techniques
•Ability to analyze, interpret, and present data in a clear manner
•Eager to learn new skills and passionate about scientific discovery and capable of independently conducting, and critically analyzing the research results with minimal supervision
•Excellent documentation and organizational, communication and interpersonal skills

Desirable skills and experience:

•Experience with virus production preferred
•Experience with qPCR or ddPCR, and flow cytometry preferred
•Experience with hematopoietic stem cells preferred

Why consider Novartis?

766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

What Novartis can offer you?

Yes, we offer exceptional benefits and competitive salaries. However, we can offer more. Here you will:

• Get access to latest technologies and work with talented scientists
• Virtually learn and earn certificates from 190 universities around the world, all supported by Novartis through our partner Coursera.
• Get access to the Novartis Learning Institute which offers personal effectiveness, digital capability and language programs, as well as talent acceleration and leadership programs.

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse team representative of the patients and communities we serve.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Cambridge, MA
Research & Development
Full Time
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Senior Scientist - Lentivirus and HSC Engineering

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