Feb 17, 2022

Job Description

186,169! That’s the number of protein structures in the Protein Data Bank. Analyzing and learning from protein structures, as well as from increasingly accurate computational models of proteins and assemblies, represent an enormous opportunity to discover new drug modalities and produce therapeutic breakthroughs for patients.

The Chemical Biology & Therapeutics (CBT) Data Science group at Novartis Institutes for BioMedical Research (NIBR) in Emeryville, CA, is seeking a talented bioinformatician to apply their protein structure expertise to preclinical research for the discovery of new drugs. The successful candidate will combine life and data science knowledge with an ability to work collaboratively with both experimental and computational scientists in a locally focused, globally integrated team.

Your responsibility

The successful candidate will join a small team of data scientists in the Bay Area to glean scientific insights from internally generated and externally curated experimental data to impact Novartis’s drug discovery portfolio. The candidate will work with local project teams in the Emeryville Protein Interactomics Center (EPICenter) and global project teams across CBT group to develop and apply computational structure-based methods to novel protein-protein interaction-based drug modalities. Finally, the candidate will devise and execute their own research agenda in alignment with experimental and computational collaborators in Emeryville and beyond.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:

• Ph.D. in bioinformatics, computational biology, or related field.
• Demonstrated strong scientific curiosity, initiative, and learning agility.
• Demonstrated ability to work as part of an interdisciplinary team (biologists, chemists, bioinformaticians, etc.).
• Demonstrated ability to present complex data science concepts in digestible terms to diverse scientific audiences (in person, in writing, virtually).
• Hands-on experience working with data derived from three-dimensional protein structures, macromolecular assemblies, and computational structure models.
• Hands-on experience applying machine learning (deep learning preferred) to experimental data.
• Experience in identifying, curating, and integrating internal and external data sources.
• Expertise working in Linux environments; high performance computing experience preferred.
• Expertise in scripting languages, such as Python or R.
• Expertise using the Python scientific stack or R tidyverse packages.
• Practical experience with relational databases (e.g., PostgreSQL).
• Track record of building custom scientific software and machine learning models.
• Track record of publishing scientific research or method development.

Why consider Novartis?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.
Emeryville, CA
Data Science
Full Time
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Structural Bioinformatician - Novartis - NIBR - Bay Area / Emeryville

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