Mar 30, 2022

Job Description

Approximately 1 billion people suffer from neurological disorders including Alzheimer’s, Parkinson’s, and psychiatric illness such as schizophrenia. The Neuroscience department at the Novartis Institutes for Biomedical Research (NIBR) has a mission to alleviate patients’ suffering by treating these and other diseases of the central nervous system (CNS).

We are seeking a highly motivated Scientist to join the Neuroscience Early Target Discovery unit to help develop human disease models and aid in target discovery and validation for a broad range of CNS disorders. You will be joining an innovative and multidisciplinary team encompassing stem cell scientists, genomics experts, and computational biologists to develop cutting-edge human cellular models and beyond. Your expertise and contributions in stem cell biology and complex cellular model development will allow us to test drug discovery hypotheses, identify patient phenotypes, and discover new targets.

Key Responsibilities:
• Maintain cultures of human pluripotent stem cells (hPSCs)
• Differentiation of hPSCs into CNS cell types such as neurons, astrocytes, and microglia
• Develop disease relevant co-culture systems (2D or 3D) to support drug discovery programs
• Develop cellular and biochemical assays for screening as well as target validation
• Employ in-house established differentiation protocols and CRISPR technologies to support neuroscience projects
• Analyze, interpret, and communicate scientific data with project teams
• Track and register human cell lines, and thoroughly document experiments in an electronic lab notebook
• Ability to work on-site


Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:
• B.S. or M.S. degree or equivalent in neuroscience, cell biology, biochemistry, or a similar discipline with at least 2 years of industry or academic research experience
• 2+ years of experience in working with hPSCs (iPS / ES), neural lineage differentiation protocols, and characterization
• Proficiency in molecular biology techniques such as PCR, qRT-PCR, ddPCR, Western Blotting, cloning, and immunostaining
• Ability to work productively in a fast-paced environment, excellent communication skills, and a collaborative mindset

Desired Qualifications:
• Experience in developing in vitro disease models for neurodegeneration / neuroinflammation targets
• Experience in high-content imaging and analysis software (e.g. CellProfiler)
• Experience in operating automated lab equipment and liquid handlers (e.g. BioTek or Hamilton systems)

Why consider Novartis?
799 million. That’s how many lives our products touched in 2019. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data.
Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

Imagine what you could do at Novartis!
Cambridge, MA
Research & Development
Full Time
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Research Scientist, Neuro Stem Cell Disease Modeling, Neuroscience

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