Dec 21, 2021

Job Description

Over 8 million people each year die from Infectious diseases, including malaria, diarrheal disease, and neglected tropical infections. In an effort to address this burden, Novartis is dedicated to finding new medicines that treat and, ultimately, contribute to the elimination of these pathogens. At Novartis, we have a long-standing history in addressing global health challenges. Today, we apply our expertise and full organizational capability to address major, unresolved global health challenges.
The Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. NIBR includes about 6500 associates across six locations worldwide. Translational Medicine (TM) is the clinical research arm of NIBR, and includes about 900 associates globally. TM plays a pivotal role in bringing innovative medicines to patients, by building on research advances to develop new therapies, and bridging drug discovery and clinical application.

The TM Discovery & Profiling (TMDP) is a group of physicians and clinical researchers who drive innovative science from discovery to the patient through the selection, profiling, and effective development of medicines. Translational medicine experts oversee Phase 1 and 2 clinical trials to demonstrate proof-of-concept (PoC) in patients, as well as support for Phase 3 development.

Our mission in the Translational Medicine Global Health Disease Area is to develop transformative therapies for the control and elimination of neglected tropical diseases and other communicable diseases with high global burden. In collaboration with a number of academic and non-profit partners, we support the discovery and development efforts of the Novartis Institutes for Tropical Diseases (one of the Institutes of NIBR) currently focused on parasitic and viral diseases, such as malaria, cryptosporidiosis, Chagas disease, leishmaniasis, and dengue. Current agents that recently started early clinical development include LXE408 for the treatment of visceral leishmaniasis and Chagas Disease, INE963, KAE609 and KAF156 for malaria, ABO809 for cryptosporidiosis, and EYU688 for the treatment of dengue.

Global Health work within NIBR is done predominantly at our sites located in Emeryville, California, and Cambridge, Massachusetts.

As a Global Health Translational Medicine Expert your primary responsibilities will include but not be limited to:

• Help to identify communicable diseases with Global Health burden and significant unmet medical need.

• Provide leadership to the Early Clinical Development project team.
 Ensure appropriate communication of project data and issues to appropriate Decision Boards, committees and groups.
 Oversee publication and external presentation of study results.

• Develop the proof-of-concept strategy for an early project.
 Culminates in the early clinical development plan implementation of the strategy in the clinic.

• Leads transition of drug candidates from the laboratory to humans and full implementation of early clinical studies
 Supervise the clinical team in designing, initiating, conducting and analyzing the data from first-in-human and proof-of-concept studies.
 Review all data, especially safety data and medical monitoring for one or more global clinical studies

• Supply medical support for relevant pharmacokinetic studies.

• Develop and implement (with operational support and input from biomarker development and clinical microbiology) the compound-related biomarker and clinical microbiology strategies.
 Recognize gaps in the availability of biomarkers needed for compound development and conceive of a practical strategy to fill those needs.

• Serve as a key representative to health authorities in matters that focus on early clinical development.

• Provide input to the research group on target selection, target validation, and pre-clinical development of compounds.
 Assess unmet medical need for different infections.
 Propose likely clinical development plans.
 Provide input on the likely use of compounds by physicians and patients.
 Review non-clinical research data and provide insight into possible clinical implications.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:

Doctoral degree, MD required with clinical subspecialty training preferred in Infectious Diseases or closely related field.
- Additional PhD/post-doctoral equivalent research preferred
- At least 5 years’ experience in a pharmaceutical/biotech company, CRO, or academic medical center, or related experience; offer will be commensurate with candidate’s level of experience.
- Recognized for medical expertise.
- Recognized for scientific expertise: respected by colleagues internally and externally, have made significant contributions to the field and created / established new concepts; record of high quality publications in international scientific journals.
- Excellent written and oral communication/presentation skills.
- Independence: Able to work independently on study planning and execution, and with supervision on project planning.
- Innovation: Seeks out new clinical discovery opportunities and PoC approaches.
- Demonstrated passion for science.
- Demonstrated leadership skills and the ability to network with and influence others.
-Ability to provide clear and logical presentations of complex strategic issues.

Experience: • 10-15 years+ experience working in a biomedical field, preferably with experience in cell & gene therapy development
• Demonstrated high intrinsic motivation to develop novel therapeutics for patients
• Experience in bringing a drug through discovery and development and/or integrating new platform technologies, especially gene therapy, to support drug discovery in a biotech/pharma research organization
• Expertise in strategic planning and program management
• Experienced in establishing/organizing/leading large cross-disciplinary teams
• Track record showing strong people leadership skills, including influencing and coaching skills, and an ability to successfully work in a highly matrixed environment
• Experienced in effectively leading across organizational boundaries
• Strong organizational skills, change agility skills and ability to manage through ambiguity.
• Strong collaborative and communicative skills. Excellent oral and written communications skills

What you’ll receive:

Competitive salary, annual bonus, long term incentive for select levels, health insurance, paid vacation/holidays, potential flexible working arrangements, employee recognition program, employee referral program

Why consider Novartis?

769 million. That’s how many lives our products touch. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

Commitment to Diversity & Inclusion:

Novartis embraces diversity, equal opportunity and inclusion. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration, and
empowers our people to unleash their full potential.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here:

We are Novartis. Join us and help us re-imagine medicine.
Translational Medicine
Cambridge, MA
Research & Development
Full Time
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Global Health Translational Medicine Expert, NIBR

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