Principal Scientist, In Vitro ADME


Job Description

9 Billion! The amount Novartis invests in Research & Development. The Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. the lives of millions.

The PK Sciences group at Novartis Institutes for Biomedical Research (NIBR)- Cambridge is seeking a highly qualified multi-disciplinary team-oriented Principal Scientist with emphasis in the area of in vitro drug transport and disposition with experience in small and large molecules.

In the role of Principal Scientist, In Vitro ADME your main responsibilities will include developing novel in vitro assays to investigate disposition of drug candidates for the optimization and characterization of ADME properties across modalities.

Your main accountabilities will not be limited to:

• Establish novel in vitro assays for evaluating absorption/permeability/transport across various cell/tissues for new chemical entities (small and large molecules), biologics.
• Provide expertise on projects teams as a subject matter expert and represent ADME as a subteam member.
• Write reports and document results for project teams as well as regulatory submissions. Present results at departmental forums as well as to project teams. Publish findings in scientific journals.
• Lead exploratory activities targeted towards developing novel in vitro systems and participate in cross functional working groups.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:

• PhD in Biochemistry, Biology, Chemistry, Bioengineering or equivalent, with a 2+ years of post-doctoral experience in a relevant field.
• Knowledge of general laboratory techniques used in the In Vitro ADME field such as, HPLC-MS, cell culture, ELISA, PCR.
• Hands on experience in evaluating in vitro drug transport.
• Expertise in 2D and 3D-cell culture models.
• Proven track record of scientific publications and presentations.
• Good organizational and communication skills and ability to multitask.
• Team player, flexible, and adaptive to changes.

Why Consider Novartis?

769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!
Translational Medicine
Cambridge, MA
Research & Development
Full Time
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Principal Scientist, In Vitro ADME

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