May 24, 2022

Job Description

1 in 15 people could be affected by a rare disease: that’s more than 400 million people all over the world! As a new Scientist in the Rare Diseases Unit, you will have an opportunity to develop innovative medicines that can improve the lives & health of patients suffering from rare genetic diseases. The Unit is looking for an experienced in vivo researcher to assume a hands-on role in a team working on rare neurodevelopmental & neurodegenerative diseases using gene therapy & other approaches.

Your responsibilities include, but are not limited to:
• Conceiving, conducting, and analyzing experiments using a variety of in vivo rodent models and study paradigms (e.g., dosing, tissue collection, analysis), in collaboration with other scientists in the Unit and across Neuroscience/Novartis Institute for BioMedical Research
• Implementing techniques for surgical and other routes of delivery of drug candidates to mouse & rat CNS
• Optimization and use of biochemical, histological, and related laboratory techniques to generate data for projects
• Writing study reports and presenting data & interpretations to internal audiences
• Writing and maintaining components of IACUC protocols and required documentation

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you'll bring to the role:
• A minimum of a Bachelor’s degree in neuroscience, in vivo pharmacology, or a related discipline
• A minimum of one year of laboratory-based industrial or academic experience
• Experience in rodent experimentation, including stereotaxic brain surgery, central (e.g., neonatal & adult intracortical injections) & peripheral (e.g., IV, RO) dosing, and advanced necropsy techniques (e.g., CSF collection, brain/spinal cord microdissection & extraction)
• Strong knowledge of CNS anatomy and at least basic knowledge of CNS physiology
• Ability to work under minimal supervision; team-oriented & collaborative mindset
• A self-motivated and pro-active attitude, with the ability & desire to multi-task; can plan ahead and follow through with completion of multiple, multi-part tasks over a range of timeframes to meet deadlines
• Excellent problem solving, organizational, and experimental management skills
• Ability to recognize and troubleshoot experimental & data anomalies to maintain high data quality
• A results-driven mentality with a sense of urgency and commitment to the goals of our mission
• Strong written and verbal communication skills; can clearly communicate challenges and resource/support requests to assist with work

Desirable requirements:
• M.S. degree or equivalent in neuroscience, in vivo pharmacology, or a related discipline
• At least five years of experience, at least half in an industrial setting
• Proficiency with assay development and implementation in one or more of the following domains: nucleic acids (e.g., RT-qPCR), biochemistry (e.g., Western blotting, ELISA, MSD), immunohistochemistry (e.g., brain sectioning, antibody labeling, light microscopy, image analysis), electrophysiology (e.g., multi-electrode array recordings)
• Experience with designing and conducting PK/PD/efficacy studies
• Experience using electronic laboratory notebooks (ELNs) with a good record of accurate, comprehensive, and timely completion of study entries
• Experience with in vitro workflows including cell culture (including hiPSC-derived neurons), immunocytochemistry, and related analysis approaches is a plus
• Experience with mouse models of neurodevelopmental and also neurodegenerative and/or psychiatric disorders are major pluses
• Familiarity with basic statistical analyses and how to apply these to biological data
• Flexibility and willingness to occasionally adjust your hours as required by specific experiments

769 million lives were touched by Novartis medicines in 2020 and, whilst we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life is the risk of never trying! Imagine what you could do at Novartis!

Commitment to Diversity & Inclusion:
Novartis embraces diversity, equal opportunity and inclusion. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration, and empowers our people to unleash their full potential.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.Novartis.com/network
Cambridge, MA
Research & Development
Full Time
careers default image

In Vivo Scientist, Neuroscience Rare Diseases

Apply to Job Access Job Account