Research Scientist, Antibody Discovery

Jan 13, 2022

Job Description

6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients.

The Biologics Center (NBC) is accommodated within the Novartis Institutes for BioMedical Research (NIBR). NBC, in collaboration with the disease areas and technical expert groups, builds the future biologics therapy pipeline of Novartis through the discovery and creation of new antibody, protein, nucleic acid and virus-based molecules.

We are looking for a Research Scientist II for the Antibody Discovery group in Cambridge, MA. You will participate in the generation of high-quality biologics for use as radioligand therapies to initiate and competitively advance the biologics pipeline by independently performing antibody screening followed by binding and functional characterization.

What you’ll be doing:
• Apply multiple cutting-edge selection techniques to synthetic and immune antibody libraries, like phage display, yeast display, FACS sorting, plate-based screening.
• Use automation to support antibody production, purification, and screening
• Sub-clone hits into expression vectors and produce them at micro-scale in a high-throughput manner.
• Characterize binders’ properties in various affinity and activity assays, like ELISA, iQue, FACS, Octet, epitope binning, reporter gene assays.
• Engineer and improve binders by means of affinity maturation or humanization.
• Generate hypotheses to test, troubleshoot issues, design and execute the next set of experiments with the input from senior team members/manager.
• Document the results in a detailed manner in Laboratory journal and in internal Databases.
• Present research updates and participate constructively in working project teams and at laboratory group meetings.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

• B.S. in Biological Sciences with 3+ years or M.S. in Biological Sciences with 1+ year of laboratory experience in antibody discovery technologies, including at least one technology, such as phage or yeast display.
• Solid background in molecular biology, cell biology, biochemistry, affinity assays.
• Self-motivation, enthusiasm, and scientific curiosity.

• Experience in antibody engineering, especially affinity maturation
• Knowledge in flow cytometry (analysis and sorting)

You’ll receive:
Competitive salary, annual bonus, pension scheme, share scheme, health insurance, 25 days annual leave, flexible working arrangements, subsidized dining facilities, employee recognition scheme and learning and development opportunities as well.

Why Novartis?
769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!
Cambridge, MA
Research & Development
Full Time
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Research Scientist, Antibody Discovery

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