Research Scientist – Sickle Cell Disease; Hematology

Sep 03, 2021

Job Description

305000 births were affected by Sickle cell disease (SCD) in 2010, the most common genetic hematological disorder, with millions of people currently affected across the globe, the majority in low and middle income countries. The condition can cause extreme pain, life-threatening infections and other complications such as stroke or loss of vision. The disease can interfere with many aspects of the patient’s life, including education, employment and psychosocial development resulting in significant socio-economic impact. Do you want to be part of early drug discovery projects that can ultimately affect the treatment for Sickle Cell Disease that would have the ability to be accessible to all patients? The Novartis Institutes for Biomedical Research (NIBR) is the innovation engine of Novartis, focusing on leveraging the breadth of innovation and novel modalities in the development of breakthrough therapies for patients. The exploratory Disease Area X (DAx) department at NIBR is looking for a highly motivated Senior Scientist to develop innovative, ground-breaking in vivo therapies for Sickle Cell Disease. DAx is a highly dynamic and collaborative drug discovery department that interfaces innovative biology, genetic engineering, gene and cell therapy platforms, genome analysis, different modalities with pre-clinical development and translational medicine.

Your responsibilities include, but are not limited to:

- Will assume a crucial role in the development of novel therapeutic concepts and will contribute at all stages of a project, from inception, early project validation, optimization, candidate selection and through to early clinical development of novel medicines for patients with sickle cell disease

- Will work collaboratively with other specialists to develop project strategy, identify key drug discovery issues, propose and implement creative solutions, execute and guide teams to success and decision points.

- They will conduct early research to develop in vivo targeted gene delivery strategies for Sickle Cell Disease

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you’ll bring to the role:

- The candidate will have an ability to work independently in experimental execution and data analysis

- Ability to perform mouse handling techniques, bleeding, and injection procedures related to HSC research

- Proficiency in molecular cloning, sequence and protein analyses, and real-time PCR; cell culture, transfection and transduction methods and flow cytometry analyses of blood lineages;

- Proficiency in using viral and non-viral based gene transfer methods including lentivirus vector design, cloning, preparation, and transduction

- Experience in ex vivo/in vitro and in vivo systems to study HSC biology

- Experience in characterization of gene function using murine models

- Possess in-depth knowledge of literature methodology, instrumentation and underlying principles of hematopoietic stem cell (HSC) biology

- Creative problem-solving skills; excellent analytical, communication and organizational skills.

Desirable requirements:

- MS or equivalent in a scientific field such as biology, chemistry or pharmacology with appropriate and relevant years of experience, or BS with appropriate and relevant years of experience in drug discovery or other related laboratory research

- Experience in a laboratory focused on hematopoietic stem cells

- Passion for working in an interdisciplinary, collaborative research environment

Why consider Novartis?

769 million patients were impacted by Novartis products in 2020. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous, and collaborative people like you are brought together in an inspiring environment. Where you are given opportunities to explore the power of digital and data. Where you are empowered to risk failure by taking smart risks, and where people who share your determination to tackle the world’s toughest medical challenges surround you.

We are Novartis. Join us and help us reimagine medicine.

Commitment to Diversity & Inclusion:

Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Cambridge, MA
Research & Development
Full Time
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Research Scientist – Sickle Cell Disease; Hematology

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