Senior Scientist - Biomarker Development, Translational Medicine

Sep 01, 2021

Job Description

1 reimagine medicine! This is an exciting opportunity to join the Molecular & Cellular Sciences (MCS) team within Biomarker Development (BMD) and Translational Medicine (TM) at the Novartis Institutes for Biomedical Research (NIBR). BMD focuses on delivering fit for purpose integrated biomarkers using diverse expertise and knowledge in immunology, genomics, protein and cellular biology and state of the art data sciences.

Our innovative spirit enables the development and application of ground breaking technologies which address key clinical questions to define disease stage or progression, predict the safety or efficacy of medication, select a group of patients who would benefit most from a given therapy, and identify additional clinical indications suitable for a drug.

As a Senior Scientist within MCS in BMD, you will work in close collaboration with project and clinical teams to develop novel exploratory assays, implement internal and external biomarker activities and interpret results to enable proof of mechanism, proof of biology, safety and efficacy understanding. You will be developing and validating innovative biomarker solutions as a cellular biomarker assay expert, implementing new methodologies, delivering high quality data and playing a pivotal role in early phase human clinical trials.

Your responsibilities will include, but not limited to:

- Develop, validate and implement innovative cellular and soluble biomarker assays with focus on flow cytometry assays for clinical studies

- Generate and interpret data to enable proof of mechanism, dose selection & proof of biology across early clinical programs and present results at internal meetings

- Partner with outsourcing functions to evaluate new CROs, drive transitioning and monitoring of internally developed assays to external vendors

- Conduct activities according to the appropriate SOPs and guidelines in compliance with Novartis quality expectations and Values and Behaviors

- Develop knowledge in additional biomarker modalities and/or technologies

- Network internally and externally to expand scientific and technical knowledge

Our Expectations:

- Develop and validate fit-for-purpose biomarker solutions

- Independently design, execute, and interpret experiments

- Ensure high quality and timely delivery of internal and external results

- Providing subject matter expertise for transferring, implementation and monitoring of assay development, validation and sample analysis at external provider

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:

- BS/MS degree in Biology, Immunology, Cell biology, or equivalent and 5+ years of relevant professional experience.

- Experience in multicolor flow cytometry and related software analysis.

- Experience in Immunology, working with primary cell culture and immune cell assay techniques.

- Professional experience in the pharmaceutical or biotechnology environment, particularly in clinical biomarker development and bioanalytical assays for cellular and soluble biomarkers is preferred.

- Ability to communicate effectively with excellent presentations skills.

- Understanding of regulatory requirement relevant to Biomarker Development (e.g. GCPLP, ICH)

- Demonstrable experience with any of the following: DIVA, FlowJo, FCSExpress, WATSON LIMS, SMART Book, Soft MaxPro, Spotfire, GraphPad Prism, etc

What Novartis can offer you?

Yes, we offer exceptional benefits and competitive salaries. However, we can offer more. Here you will:

- Work with the latest technologies and applications

- Get a first-hand experience in Translational Medicine for human clinical trials

- Be part of a world class organization dedicated to providing solutions to unmet medical needs

- Join an organization that is committed to your development and advancement

Why consider Novartis?

769 million patients were impacted by Novartis products in 2020. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you are given opportunities to explore the power of digital and data. Where you are empowered to risk failure by taking smart risks, and where people who share your determination to tackle the world’s toughest medical challenges surround you.

We are Novartis. Join us and help us reimagine medicine.

Commitment to Diversity & Inclusion:

Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Translational Medicine
Cambridge, MA
Research & Development
Full Time
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Senior Scientist - Biomarker Development, Translational Medicine

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