Research Scientist II - Mammalian Protein Expression (80-100%*)

Sep 14, 2021

Job Description

6000! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients. The Biologics Center (NBC) is housed within the Novartis Institutes for BioMedical Research (NIBR). NBC, in collaboration with the disease areas and other platform groups, builds the future biologics therapy pipeline of Novartis through the discovery and creation of new antibody, protein, nucleic acid and virus-based molecules.

As a member of the large-scale expression team, you will support the production of recombinant proteins in mammalian cells and ensure the supply of antigens, antibodies, tool proteins and therapeutic proteins for global NIBR research projects. You will work in close collaboration with the colleagues in the protein production group as well as with other scientists across NBC to support the NIBR biologics pipeline.

Your responsibilities will include, but are not limited to:

• Expansion and maintenance of mammalian cells in suspension from small to large scale (up to 100L)
• Use transiently and stably transfected HEK293 or CHO cells for the expression of recombinant antibodies, antibody fragments and proteins
• Expansion of hybridoma cells for protein production
• Generate hypotheses to test, troubleshoot issues and design and execute the next set of experiments with some input from senior lab members/manager
• Collaboration and data archiving for our CMO outsourcing partner
• Literature search to develop and implement novel technology solutions
• Active participation in lab organization including maintenance of equipment and preparation of sterile devices for production
• Detailed documentation of results, present research updates and participate constructively in working project teams and at lab meetings

Diversity & Inclusion / EEO

Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.

Minimum Requirements

What you will bring to the role:

• Completed Apprenticeship or University degree in a relevant life science discipline or equivalent
• Good theoretical and practical laboratory experience in mammalian cell technology (transient transfection, stable cell lines, Wave culture systems), cell biology and sterile technique
• High learning ability to acquire expertise in new technologies and technical equipment
• Proven experience in successfully prioritizing and keeping timelines
• Excellent organization skills; ability to run multiple projects in parallel
• Independent and accurate working style, results-driven and committed to quality
• Open and proactive communication, strong customer focus, ability to interact with various partners
• Reliable and flexible team player, used to share tasks and projects
• Fluency in English (oral/written); German advantageous

Desirable Skills

• Solid experience in at least one of the neighboring disciplines (Molecular Biology, Protein Purification)
• Generation of expression vectors for various production systems
• Purification of antibodies and proteins using various chromatographic techniques and analytical tools to ensure delivery of high quality material

Commitment to Diversity & Inclusion:
Novartis embraces diversity, equal opportunity and inclusion. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration, and empowers our people to unleash their full potential.

* Some restrictions on flexible working options may apply and will be discussed during interview if applicable.

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Why Novartis?

769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to proactively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!
Research & Development
Full Time
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Research Scientist II - Mammalian Protein Expression (80-100%*)

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