Senior Scientist, Antibody Discovery

325400BR
Oct 10, 2021
USA

Job Description

6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients. The Biologics Center (NBC) is accommodated within NIBR. NBC, in collaboration with the disease areas and technical expert groups, builds the future biologics therapy pipeline of Novartis through the discovery and creation of new antibody, protein, nucleic acid and virus-based molecules.

We are seeking a Senior Scientist that is highly motivated, flexible and an adaptive team player for the Antibody Discovery group within NBC in Cambridge, MA. In this role, you will participate in the generation of high-quality biologics to initiate and competitively advance the NIBR biologics pipeline by independently performing antibody screening followed by binding and functional characterization.

Your key responsibilities:
• Apply multiple cutting-edge selection techniques to synthetic and immune antibody libraries, like phage display, yeast display, FACS sorting, plate-based screening.
• Use automation to support antibody production, purification, and screening
• Sub-clone hits into expression vectors and produce them at micro-scale in a high-throughput manner.
• Characterize binders properties in various affinity and activity assays, like ELISA, iQue, FACS, Octet, epitope binning, reporter gene assays.
• Engineer and improve binders by means of affinity maturation or humanization.
• Generate hypotheses to test, troubleshoot issues, design and execute the next set of experiments with the input from senior team members or manager.
• Document the results in a detailed manner in laboratory journal and in internal databases.
• Present research updates and participate constructively in working project teams and at laboratory group meetings.


Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
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NIBR
BIOTHERAPEUTIC AND ANALYTICAL TECHNOLOGIES - NIBR
USA
Boston, MA
Research & Development
Full Time
Regular
No
325400BR

Senior Scientist, Antibody Discovery

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