Senior/Principle Scientist, PK Sciences Global Biotransformation

324960BR
Aug 05, 2021
USA

Job Description

100,000 + people across 140 countries are working for Novartis to discover, develop and successfully market innovative products to prevent and cure diseases, to ease suffering, and to enhance the quality of life!

Biotransformation is a key field within PK Sciences driving the pivotal development of small molecules and new modalities such as drug-protein conjugates, oligonucleotides, peptides and radioligands from preclinical discovery into human and up to regulatory filing.

PK Sciences is currently seeking to fill multiple positions for our biotransformation team in Cambridge, MA at the Senior Scientist and/or Principle Scientist levels. The final level and title of the offered role will be determined by the hiring team based on the skills, experience, and capabilities of the applicant. In these roles, you will be joining a large global team of skilled and motivated drug metabolism scientists who closely collaborate with other groups both within and outside of PKS in a highly cross-functional environment.

As a successful candidate you will be adaptable, independently motivated, and challenge driven with a history that demonstrates strong interpersonal skills that encourage successful collaborative working relationships. In these roles, you will work in a team environment to support programs through the conduct of drug metabolism studies designed to understand biotransformation pathways and routes of elimination of diverse therapeutic modalities. Your major responsibilities will include planning, conducting and documenting experiments designed to investigate metabolic pathways and structural elucidation of metabolites formed from new drug candidates. Candidates who have experience with immunoprecipitation, intact protein, oligonucleotide, and/or peptide analysis will be highly desired. You will also be given many opportunities to diversify your skills and develop your career.

Your main accountabilities will include but not be limited to:
• Develop and perform assays to characterize the metabolism of new modalities such as protein-drug conjugates, oligonucleotides, fusion proteins, and radio-ligand therapies
• Design and execution of biotransformation studies to assess metabolic pathways, soft-spot identification, structural elucidation, and bioactivation of drug candidates
• Organize and prepare experimental protocols and study reports with upload of results to a centralized database
• Assure quality standard guidelines and safe work practices are applied while working in the laboratories
• Candidates at the Principle Scientist level will also be asked to plan and monitor discovery, pre-clinical, and clinical development ADME studies (in vitro and in vivo) to aid in drug candidate progression
• Additionally, candidates at the Principle Scientist level will be asked to participate in technical and/or scientific initiatives to drive innovation at Novartis

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
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NIBR
Translational Medicine
USA
Cambridge, MA
Research & Development
Full Time
Regular
No
324960BR

Senior/Principle Scientist, PK Sciences Global Biotransformation

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