Principal Scientist I/II – M&S PK Sciences, PBPK and Data Science

322717BR
Sep 30, 2021
USA

Job Description

750 million+. That’s the number of lives our products touch. While we’re proud of that fact, in this world of digital and technological transformation, we must continue to improve and extend even more people’s lives. We believe we can achieve the goal when curious, courageous and collaborative people like you are brought together in an inspiring environment, empowering you to take calculated risks, and teaming you with people who share your determination, to tackle the world’s toughest medical challenges.

As Principal Scientist in the Modeling&Simulation group in PK Sciences (PKS), you support global small molecule drug discovery projects teams by pharmocokinetics guidance, integration of machine learning, PBPK(PD) modeling and data analytics.

You contribute to setting new standards in the way we guide project teams on selecting drug candidates with decent ADME/PK properties and moving them into clinical development.

In this role you will:
• Support the selection of molecules for efficient lead optimization and hypotheses testing by identification of pharmacokinetic liabilities
• Contribute to developing a modelling-based strategy for preclinical projects and lead the project team discussions on the human dose prediction prior to candidate selection
• In collaboration with Data Scientists and QSP modelers, set up a modeling workflow that will allow improving efficiency by automation and understanding the relationship between structure and properties in vitro and in vivo
• Integrate data and machine learning models to assess how exposure will change with dose and across species using PBPK and QSP/PK/PD modeling
• Promote the use of innovative approaches within the organization, through scientific collaborations, publications in scientific peer reviewed journals and presentations at professional meetings

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

• PhD in Chemistry, Computational Biosciences, Pharmacokinetics modeling, or another relevant Life Science discipline, with a focus on drug discovery and medicinal chemistry
• Experience in medicinal chemistry with knowledge in pharmacokinetics and computational data science
• Ideally, knowledge of PBPK modeling in the context of drug absorption, distribution, elimination and relevant simulation software; ideally experience with PK-SIM and R
• Demonstrated expert knowledge in influencing medicinal chemistry teams by ADME/PK/PD simulation results and in identifying potential PK/PD related risks
• Strong interpersonal communication skills and ability to manage in a dynamic, ever-changing working environment
• Proactive, self- motivated and independent working style. Excited about working in a global, multidisciplinary team and understanding the needs and goals of the broader organization
• Ability to drive for results with a sense of urgency, courage and innovative thinking.
• Fluent in English (oral and written)

WHY NOVARTIS?
769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.

Join our Novartis Network : If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
NIBR
Translational Medicine
USA
Cambridge, MA
Research & Development
Full Time
Regular
No
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322717BR

Principal Scientist I/II – M&S PK Sciences, PBPK and Data Science

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