Principal Scientist, Modeling & Simulation

Jun 29, 2021

Job Description

750 million+. That’s the number of lives our products touch. While we’re proud of that fact, in this world of digital and technological transformation, we must continue to improve and extend even more people’s lives. We believe we can achieve the goal when curious, courageous and collaborative people like you are brought together in an inspiring environment, empowering you to take calculated risks, and teaming you with people who share your determination, to tackle the world’s toughest medical challenges.

As Principal Scientist in the Modeling & Simulation group within PK Sciences and Translational Medicine at the Novartis Institute for Biomedical Research (NIBR) you will have an exciting opportunity to accelerate the discovery and development of radioligands. You will contribute to setting new standards in how to guide discovery project teams on selecting the best radioligand drug candidates and moving them towards the clinic. You will collaborate with global drug discovery project teams by applying PBPK modeling in combination with dosimetry analysis to provide model-informed guidance for First-in-Human dosing strategies.

Your responsibilities will include, but are not limited to: 

• Accelerating the selection of molecules for efficient discovery and lead optimization as well as hypothesis testing, by identifying desirable pharmacokinetic characteristics of novel radioligands.
• Developing and executing a modeling-based strategy for preclinical projects and lead project team discussions on the human dose prediction prior to candidate selection.
• Using PBPK modeling to integrate data and knowledge across preclinical and clinical programs and assess how radioligand exposure will change with dose and across species
• Using PBPK modeling and dosimetry analysis to translate preclinical radioligand exposure and design optimal radioligand clinical dosing strategies
• Implementing innovative and quantitative approaches to advance translational sciences for radioligand theragnostics.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:

Minimum requirements:

• PhD with relevant experience in radiobiology or related physics/biology/chemistry/ engineering/mathematics background
• 2+ years of experience in drug discovery/development or other relevant experience.
• Broad understanding of radiobiology and dosimetry analysis, expertise in PBPK modeling is a plus.
• Demonstrated quantitative expertise in the application of ODE-based models (MatLab, R)
• Strong interpersonal communication skills and ability to manage in a dynamic, ever-changing and interdisciplinary working environment.
• Fluent in English (oral and written)


769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion:

Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.
Translational Medicine
Cambridge, MA
Research & Development
Full Time
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Principal Scientist, Modeling & Simulation

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