Senior Principal Scientist, Alzheimer’s Disease Research

Jun 24, 2021

Job Description

50 million people across the globe that suffer from Alzheimer’s are waiting for effective, tailored therapies to arrest the progression of this relentless disease. Novartis is dedicated to discovering and developing groundbreaking therapies for serious neurological disorders. This is an opportunity to create and advance life-changing therapies for patients suffering from Alzheimer’s disease.

Your key responsibilities:

The Senior Principal Scientist of Alzheimer’s disease will lead drug discovery programs in Alzheimer’s disease and related neurodegenerative diseases and contribute to Alzheimer’s disease therapeutic strategy, reporting to the Head of Neurodegeneration. Your responsibilities include, but are not limited to:

- Develop and lead drug discovery programs focused on Alzheimer’s disease and related neurodegenerative disorders using the multiple modalities available to Novartis and ranging in stage from exploratory to clinical proof-of-concept (PoC)

- Collaborate with the Head of Neurodegeneration, internal and external experts and the Neuroscience Leadership Team (NSLT) to refine and execute on Novartis’ Alzheimer’s disease strategy

- Identify and pursue innovative targets for Alzheimer’s disease and related neurodegenerative disorders based on high-quality human and experimental data

- Communicate & collaborate across the organization to advance Alzheimer’s disease and neurodegeneration strategy & portfolio priorities

- For each program, define key experiments critical for target validation, and in vitro and in vivo pharmacology, in order to establish a strong case for PoC

- Manage and mentor research scientists, focusing on Novartis’ values and culture to most effectively deliver on NS objectives and develop NS talent.

- Share deep expertise in Alzheimer’s disease etiology and pathophysiology during drug discovery, drug development, and business development decision making

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you’ll bring to the role:

- PhD in neuroscience, biology, pharmacology or a related subject area and at least 5 years of proven experience in Alzheimer’s disease research in the pharmaceutical/biotech industry.

- Deep understanding of relevant disease biology.

- Strong record of leading teams, presenting to decision boards and demonstrated ability to influence at the Leadership Team level

- Ability to drive to data-based decisions involving internal and external partners so as to deliver on organizational goals

- Ability to communicate effectively at all levels and present complex and/or new ideas with clarity and simplicity

- “portfolio mentality” to advance the highest potential programs regardless of origin

Desirable Skills:

- Experience in more than one therapeutic modality including low molecular weight molecules, antibodies, oligonucleotides, gene therapy

- Experience evaluating novel delivery mechanisms for crossing the blood brain barrier

Why consider Novartis?

769 million. That’s how many lives our products touched in 2020. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

Imagine what you could do at Novartis!

Commitment to Diversity & Inclusion:

Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Cambridge, MA
Research & Development
Full Time
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Senior Principal Scientist, Alzheimer’s Disease Research

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