Principal Scientist I/II – M&S PK Sciences, PBPK and Data Science

321425BR
Oct 14, 2021
Switzerland

Job Description

750 million+. That’s the number of lives our products touch. While we’re proud of that fact, in this world of digital and technological transformation, we must continue to improve and extend even more people’s lives. We believe we can achieve the goal when curious, courageous and collaborative people like you are brought together in an inspiring environment, empowering you to take calculated risks, and teaming you with people who share your determination, to tackle the world’s toughest medical challenges.

As Principal Scientist in the Modeling&Simulation group in PK Sciences (PKS), you support global small molecule drug discovery project teams by by pharmocokinetics guidance, integration of machine learning, PBPK(PD) modeling and data analytics.

In this role you will

• Support the selection of molecules for efficient lead optimization and hypotheses testing by identification of pharmacokinetic liabilities
• Contribute to developing a modelling-based strategy for preclinical projects and lead the project team discussions on the human dose prediction prior to candidate selection
• In collaboration with Data Scientists and QSP modelers, set up a modeling workflow that will allow improving efficiency by automation and understanding the relationship between structure and properties in vitro and in vivo
• Integrate data and machine learning models to assess how exposure will change with dose and across species using PBPK and QSP/PK/PD modeling
• Promote the use of innovative approaches within the organization, through scientific collaborations, publications in scientific peer reviewed journals and presentations at professional meetings

Diversity & Inclusion / EEO

Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.

Minimum Requirements

Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.
NIBR
Translational Medicine
Switzerland
Basel
Research & Development
Full Time
Regular
No
321425BR

Principal Scientist I/II – M&S PK Sciences, PBPK and Data Science

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