Neuroscience Physician Scientist, Neurology

320140BR
May 29, 2021
USA

Job Description

2 Billion plus people are affected by diseases of the nervous system having a dramatic impact on patients and families around the world. Neurologic and psychiatric diseases remain as some of the largest challenges in medicine. Novartis is committed to changing the landscape by developing transformative treatments for important neuroscience disorders.

The Translational Medicine (TM) Discovery & Profiling (TMDP) group within the Novartis Institutes for BioMedical Research (NIBR) is a team of physicians and clinical researchers who drive that innovation science from discovery to the patient through the selection, profiling and effective development of medicines.

In the role of Neuroscience-Psychiatry TM Expert (TME) you will develop high value decision-strategies for the Translational Medicine component of drug development projects through the proof-of-concept phase.

Your main accountabilities will include but not be limited to:
• Lead project teams that develop and implement strategies in early drug discovery and profiling programs for First-in-Human safety (phase 1) and clinical Proof of Concept efficacy (phase 2a) studies.
• Design and execute Clinical Pharmacology and Experimental Medicine clinical studies.
• Collaborate with preclinical research scientists to identify, develop, and implement strategy for support of early drug discovery objectives. This includes assessment of medical need, proposal of clinical development pathways, and review of preclinical data for clinical implications, and other relevant activities.
• As medical monitor, ensure safety of participants in early-stage clinical studies.
• Participate in regulatory activities, including preparation and submission of Investigator Brochures (IB), IND submissions, and other Health Authority Interactions.
• Work closely with biomarker experts to develop and implement compound related biomarker strategies and implementation.
• Develop novel clinical endpoints, including digital approaches.
• Provide scientific expert assessments and support for in-licensing opportunities, including due diligence activities.
• Drive success of late global drug development programs (phases 2b and 3) when appropriate by developing and implementing strategies that lead to clinical pharmacology, design of mechanistic studies and profiling packages that meet regulatory requirements and support differentiated and competitive drug labeling

Position can be located in Cambridge, MA or Basel, Switzerland

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:

Minimum Requirements:

• Medical Degree and additional PhD/post-doctoral equivalent research
• Specialized further training (board certification) and / or clinical research experience in neurodegenerative disorders preferred
• Advanced / business-level / fluent English (oral and written)
• Recognized for medical expertise: demonstrated excellence and clinical / patient expertise in psychiatry
• Recognized for scientific expertise: respected by colleagues internally and externally, you’ve made significant contributions to your field and created / established new concepts; record of high quality publications in international scientific journals.
• Previous relevant & significant clinical study experience: either from pharma/biotech leading early phase clinical trials; a senior role within a CRO responsible for leading the medical relationship with Sponsors; from a relevant academic medical center with PI & co-PI clinical trial experience. You are used to working independently and within teams including scientists and non-scientists on study planning and execution, demonstrating competence in a broad range of project and more strategic planning skills
• Excellent written and oral communication/presentation skills, used to distilling and effectively conveying significant messages to different audiences


The ideal candidate will be:
• A physician-scientist with good familiarity of modern basic neuroscience
• Familiar with current clinical management, with experience in neurodegenerative disorders preferred
• Highly collaborative with superior interpersonal skills
• Mission-driven to improve the lives of patients with neurologic and psychiatric disorders
• Agile enough to approach multiple different diseases
• Intellectually curious, but results-driven
• Proven ability to lead multidisciplinary teams to success

Position offered will be commensurate with level of experience.
NIBR
Translational Medicine
USA
Cambridge, MA
Research & Development
Full Time
Regular
No
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320140BR

Neuroscience Physician Scientist, Neurology

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