Scientist/Sr. Scientist – Protein Engineer/Biologist, Tissue Targeting

Scientist/Sr. Scientist – Protein Engineer/Biologist, Tissue Targeting

Job Description

6000! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR).

We are seeking a highly motivated scientist with expertise in tissue targeting of biological therapies to join a dynamic and experienced cell and gene therapy team at Novartis pushing new frontiers in targeted vector design and gen(om)e editing aiming to develop one-time curative therapies for sickle cell disease and HIV.

This position resides in the Biotherapeutic Engineering and Gene Therapy (BEGT) group within NBC in Cambridge, Massachusetts. The BEGT group drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNA therapeutics, AAV and lentiviral vectors. Working collaboratively with Disease area groups BEGT broadens the use of biologics in therapeutic applications where conventional antibodies have limitations.
What you'll be doing:
• Work collaboratively with a focused team to develop effective and efficient in vivo viral and nonviral delivery methods to hematopoietic stem cells (HSCs).
• Target receptor identification and validation for HSCs
• Evaluate and implement novel approaches for tissue specific targeting.
• Targeting ligand identification and optimization using phage or yeast display and/or rationale design.
• Bridge protein engineering expertise, conjugation and capsid or nanoparticle engineering to develop next generation cell-specific gene delivery facility for hematopoetic stem cells
• Functional characterization of novel viral and nonviral constructs via in vitro cellular assays, imaging and FACs for selectivity and activity.
• Offer innovative, proactive approaches to scientific questions and troubleshooting efforts
• Identify unmet needs and collaborate for novel solutions
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum requirements

What you'll bring to the role:
• Ph.D. with 0-2 years postdoctoral experience or BS/MS with more than 5 years confirmed experience in a relevant field.
• A deep understanding and validated technical expertise in protein conjugation techniques.
• Experience in targeted delivery of proteins, peptides, small molecules, viruses or nanoparticles.
• Extensive experience in cell culture and transfection including isolation and culture of primary cells
• The ability to work independently in experimental design, execution and data analysis
• Highly collaborative spirit, good communication skills, creativity, and multi-tasking in a fast-paced environment
• Prior experience working with HSCs is a plus.

Why consider Novartis?

799 million. That’s how many lives our products touch. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

Imagine what you could do at Novartis!
Cambridge, MA
Research & Development
Full Time