Principal Scientist – Lentiviral Vectors (80- 100%)

Principal Scientist – Lentiviral Vectors (80- 100%)

Job Description

200+! Projects in clinical development. That’s the number of projects which keep us busy!
At the Biologics Center at Novartis Institute for Biomedical Research (NIBR) in Basel, we are developing innovative therapeutic approaches for our Cell & Gene Therapies portfolio and advance our viral vector platform for the next-generation of CAR-T cell therapies.
To help us to achieve our goals we are looking for a highly motivated and curious scientist to join our team at the exciting interface between research and development with close connections to our CGT manufacturing sites. You will work on the optimization of the current viral vector expression platforms by engineering improved lentiviral vectors and developing lentiviral producer cell lines. You will contribute to the definition of manufacturability parameters by the establishment of efficient small scale models for virus production and the detailed characterization of viral vectors.
Your responsibilities will include, but are not limited to:
• Contributing to strategy, design and development of state-of-the-art lentiviral packaging and producer suspension HEK cell lines, including hands-on execution
• Optimization of lentiviral vectors and encoded genetic elements for optimal viral production, efficient transduction of human primary cells and expression of transgenes, including hands-on execution
• Establishment of small scale models for screening and ranking of diverse viral vector designs and producer cell lines to identify best manufacturability parameters for transfer to Cell and Gene Therapy Technical Development, including hands-on execution
• Characterization of lentiviral vectors using state-of-the-art molecular biology techniques, including hands-on execution
• Contribute to the design of cell line engineering strategies for the development of superior lentiviral vector producer cell lines including the establishment of regulatable genetic switches
• Mentoring/supervision of lab associates
• Collaborating with scientists in the research project teams to address target and therapy’s specific needs and working with scientists in the Cell and Gene Therapy Technical Development unit to address process development and manufacturing specific needs

Minimum requirements

What you’ll bring to the role:
• PhD in bioengineering, virology, gene therapy, molecular biology, genetics, or a related field with several years of relevant laboratory experience
• In-depth knowledge of literature, methodology, and biotech/pharmaceutical industry developments in the field of lentivirus/CAR-T cell-related cell & gene therapy. Experience with biologics and/or CAR-T cell research and development is desired
• Experience working in a BSL2 environment
• Experience with lentiviral vector design & lentivirus expression platforms in mammalian cell culture
• Excellent oral and written communication and interpersonal skills as well as commitment to mentorship and developing the careers of others and yourself.
• You are driven by self-motivation, enthusiasm, and scientific curiosity
• Fluency in English

What can we offer:
• There is much more beyond competitive salary, and exceptional benefits which we offer
• An organization that is committed to your development and advancement
• Working in the motivating environment with the latest cell & gene therapy technologies, and the true pioneers in the field
• Opportunity to translate lentivirus and CAR-T cell research advancement into effective therapies
• Be a part of a drug discovery and development with the novel biologics class in the established pharma setting

Why consider Novartis?

799 million. That’s how many lives our products touched in 2019. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

Imagine what you could do at Novartis!

Commitment to Diversity & Inclusion:

Novartis embraces diversity, equal opportunity and inclusion. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration, and empowers our people to unleash their full potential.

*Some restrictions on flexible working options may apply and will be discussed during interview if applicable.

Join our Novartis Network:

If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here:
Novartis Pharma AG
Research & Development
Full Time