Investigator - Computational ADME, Data Integration and Modeling

Investigator - Computational ADME, Data Integration and Modeling

Job Description

6500! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. Translational Medicine (TM) is the clinical research arm of NIBR, and includes about 1000 associates globally. TM plays a pivotal role in bringing innovative medicines to patients, by building on research advances to develop new therapies, and bridging drug discovery and clinical application. Within TM, PK Sciences (PKS) partners across both NIBR and the Global Drug Development organizations to advance the scientific knowledge of pharmacokinetics, metabolism and clinical pharmacology, and bring it to bear on drug discovery and development challenges throughout R&D.

As an Investigator II in the Modeling&Simulation group within PK Sciences, you support global discovery project teams with data analysis, data integration and modeling. You have an opportunity to set new standards in the way we guide project teams to identify drug candidates with decent ADME/PK properties and moving them into clinical development.

Your responsibilities include, but are not limited to:

• Supporting the selection of molecules for efficient lead optimization and hypotheses testing from an ADMET/PK viewpoint. Moreover, you will provide model interpretation and MedChem input for the design of new molecules.
• In collaboration with computational chemistry, setup and support data mining tools to understand relationship between structure and properties in vitro and in vivo
• Develop machine learning models on ADMET properties within a community of machine learning experts and ADMET scientists
• Integrate data to assess how exposure will change with dose and across species using PBPK modeling
• Address and fill scientific gaps in the computational ADMET area in collaboration with preclinical safety

Minimum requirements

What you’ll bring to the role:
• PhD in Computational Biosciences, CAAD, Pharmacometrics or another relevant Life Science discipline, with a focus on drug discovery
• At least 3 years of experience in the pharmaceutical industry with a record of accomplishment for ADME/PK or Toxicology model development and interpretation
• Demonstrated experience in converting ADME/PK observations into meaningful MedChem input
• Proven expert knowledge of in-vitro ADME assays application to predict in-vivo PK profiles and to identify potential PK-related risks
• Broad understanding of physiology in the context of drug absorption, distribution, elimination and relevant simulation software, like GastroPlus and SimCyp
• Familiarity with data analysis, integration and visualization software (e.g. Spotfire, R shiny).
• Proficiency in Machine Learning, CADD and programming languages, like Python, Scikit-Learn, RDkit, KNIME
• Strong interpersonal communication skills and ability to manage in a dynamic, ever-changing working environment.
• Fluent English (oral and written)

750 million. That’s how many lives our products touch. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are empowered to ask new questions, make bolder decisions and take smarter risks.

We are Novartis. Join us and help us reimagine medicine.
Translational Medicine
Novartis Pharma AG
Research & Development
Full Time