Translational Medicine and Data Science Expert

275216BR
Translational Medicine and Data Science Expert

Job Description

20 petabytes of data. 2 million patient-years of information. 30 data domains from preclinical through Phase 3 trials. All waiting for you to unlock the next breakthrough in medicine. If you are inspired to tackle the world’s toughest medical challenges, this is where you will unite science, data and digital technology as a Translational Medicine and Data Science Expert.

Novartis Institutes for Biomedical Research is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. Not only do we fund the majority of our own internal discovery research, the way we approach it is different too: partnering physician scientists with basic researchers and data analysts enables us to focus earlier on unmet patient need and discover where drugs will have the most impact. Translational Medicine is a group of physicians and scientists that drive innovative science from discovery to the patient through the selection, profiling, and effective development of medicines.

As a Translational Medicine and Data Science Expert you will provide medical and scientific expertise and leadership to:

• Drive the success of early global programs, develop and implement strategies to achieve clinical Proof of Concept as well as late global programs; and develop and implement strategies leading to clinical pharmacology and profiling packages that meet regulatory requirements and support differentiated and competitive drug labeling

• Support Translational Research in developing new indications, endpoints and biomarkers, using in vitro, in vivo, or in silico methods

• Apply data science methodology to identify potential indications, endpoints, biomarkers, and pathway nexi that can optimize the early clinical development strategy by collaborating with the Biomarker Development team and research discovery colleagues to integrate clinical and preclinical information into the clinical development approach.

• Apply data science methodology to develop evidence to support the full development program. This includes using internal and external data to evaluate the impact of various clinical scenario

• Provide leadership between medical and data science disciplines to leverage Novartis and external data for Translational Medicine programs.

• Provide scientific expert assessments and support for in-licensing opportunities, including due diligences

This position can be based in Cambridge, Massachusetts (USA) or Basel (Switzerland)

ABOUT TRANSLATIONAL MEDICINE
Translational Medicine (TM) is a global group of nearly 1,000 scientists and physicians working at the pre-clinical and early clinical stage of drug discovery.

Our Physician-Scientist TM Discovery & Profiling group drives innovative and cutting–edge science from Discovery to the market through the selection, profiling and effective global development of successful medicines. The group closes the gap between preclinical research and clinical development and integrates clinical science into the discovery and preclinical development phase. Our Translational Medicine concepts are driven by medical needs of the patient and the concept of personalized medicine, tailoring the drug, its dose and dosing regimen in such way to the patient that the clinical response is optimal in terms of efficacy and safety.

We focus from identification of drug targets (molecular pathways relevant to disease) up to the completion of Proof of Concept (Phase IIa studies). Our Translational Medicine Experts are part of preclinical project teams in all drug discovery phases and help design the pathway for First in Human studies (healthy volunteer) that bridge to studies in the patient population. They have the comprehensive responsibility for designing and executing the early clinical drug development phase together with a project team from researcher, biomarkers, biostatistics, modeling and simulation, toxicology, technical experts and the clinical trial teams.

After the completion of a successful Phase IIa study the drug progresses to full Development for Phase IIb and Phase III study design and further drug development. Translational Medicine Experts with an interest in profiling will often continue as members of the global project team to characterize the clinical pharmacology, the mode of action, the biomarker response of a compound, look for new potential indications, contribute to the drug approval process and profile a new compound further in the market.


The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.

Minimum requirements

What you will bring to the role:

Medical Doctor degree required; additional PhD (or PhD-level research) desirable


• Demonstrated excellence and clinical expertise in your relevant medical subspecialty, evidenced by quality scientific publications, patient experience, and significant contributions to your field over time

• Quantitative expertise in biostatistics, bioinformatics, computer science, data science or related technical field. Hands-on experience analyzing, interpreting, publishing studies consisting of a variety of omics technologies (NGS, proteomics, etc.). Formal training and demonstrated experience with machine learning, “big data” analysis, statistical approaches to exploratory analysis, or related aspects of data science

• Experience performing in a similar role within a Pharmaceutical research company, a Clinical Research Organization or an academic medical center. Used to leading complex cross-functional/matrix project teams with proven success collaborating with expert disease research scientists and non-specialists

• Recognized expert in your field, driving success for individual studies and projects; respected by a wide range of your internal colleagues and external collaborators

• Demonstrated passion for science, seeking out new clinical discovery opportunities and early clinical study approaches

• Advanced leadership, planning, prioritization, problem solving and organizational skills

WHY CONSIDER NOVARTIS?

817 million. That’s how many lives our products touched in 2018. And while we’re proud of that, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are empowered to ask new questions, make bolder decisions and take smarter risks.

We are Novartis. Join us and help reimagine medicine
NIBR
Translational Medicine
USA
Cambridge, MA
NIBRI
Research & Development
Full Time
Regular