Scientific Technical Leader I Assay Development Novartis / Emeryville

Scientific Technical Leader I Assay Development Novartis / Emeryville

Job Description

6500! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

The Emeryville Structural Based Drug Design (SBDD) Center is seeking a highly motivated scientist with strong expertise in biochemical assay development to join the Emeryville Protein Sciences Home.

Your responsibilities:

• Lead from the bench and contribute hands-on expertise to our assay development efforts in support of the EMV SBDD Center.
• Collaborate with multiple drug discovery teams contributing to the small molecule drug discovery pipeline.
• Develop, optimize and implement novel in-vitro biochemical assays and ensures successful transfer of these assays & associated protocols to other groups to support HTS and SAR studies for promising therapeutic targets.
• Readily adapt to changing project needs, semi-independently plan and execute experiments and develop sophisticated problem-identification & problem-solving skills.
• Maintain fluency with the latest scientific literature and rationale surrounding drug targets and be an active contributor to the interpretation of results in-group discussions.
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.

Minimum requirements

What you will bring to the role:

• PhD or MS/BS in Biochemistry, Enzymology or related field with a minimum of 3 years (PhD) or more than 5 years (MS/BS) industry/biotech experience
• Scientific and technical background in drug discovery, with demonstrated proficiency in assay development, optimization, and screening with small molecules.
• Established capability to rapidly design, optimize and execute novel biochemical assays including TR FRET, FP, and Alpha Screen to support HTS and SAR studies for promising novel therapeutic targets
• Extensive experience in enzymology (e.g., protein activity assessment, steady-state kinetic characterization of enzyme, substrate, and inhibitor mechanisms) is required
• Significant experience in developing biochemical assays for drug discovery, and have the ability to learn, apply, and incorporate automation solutions to assay development operations in the lab, assay troubleshooting, mechanism of action and modes of inhibition analysis, data analysis, and reporting.

Why consider Novartis?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.
Emeryville, CA
Research & Development
Full Time