Scientist I, Liver Disease

Scientist I, Liver Disease
You are applying to be part of the Novartis Talent Pool. We are not currently recruiting for this role but we are building a pipeline for future opportunities. If you would like to be considered for a similar position in future, then please submit your CV.
Job purpose

We are looking for a highly motivated and innovative scientist to join our liver disease program at China Novartis Institutes for Biomedical Research (CNIBR) located in the state-of-art Novartis campus in Zhangjiang Hi-Tech Park, Shanghai. The ideal candidate will be joining a laboratory working on metabolic aspects of chronic liver disease including NASH. S/he will be delineating disease biology and be responsible for conducting end-point analyses of pharmacology studies and other in vivo/cellular phenotypic characterization to support drug discovery effort. The successful candidate will work in a fast-paced and highly matrixed environment.

Major accountabilities
1. Design, optimize, validate and execute cellular and end-point assays based on deep understanding of target biology for programs targeting lipid metabolism in order to support individual research projects and general drug discovery efforts for hepatic disorders.
2. Use biochemical and molecular methods and cutting-edge technologies to characterize pre-clinical in vivo and ex vivo models and understand the mechanism of action (MOA) of a particular targets or to evaluate compound efficacy.
3. Analyze and interpret data independently based on critical thinking and the use of statistic tools. Present and discuss results in group and project team meetings as well as to a larger scientific audience and the site research leadership at portfolio reviews and research forums.
4. Proactively seek new perspectives or new solutions to address key scientific questions and identify novel targets to complement existing programs or expand our drug discovery pipeline.
Minimum Requirement
Master degree (with industry experience in drug discovery) in molecular biology, cellular biology, biochemistry, medicine or a related field. Freshly graduated PhD scientists will also be considered. In-depth knowledge and experience in lipid metabolism is strongly preferred.

Business-level oral and written skills in English are required.

Experience/Professional Requirement:

1. Strong hands-on experience in primary cell culture, microscopic analyses, and other basic molecular biology and biochemistry techniques, such as qPCR, western blot, immunohistochemistry, ELISA.
2. Solid understanding of carbohydrate and lipid metabolic pathways or a related field with relevant concepts. Knowledge of metabolic disorders and liver diseases are preferred.
3. Knowledge and experience in metabolite/lipid analyses and the related analytical approaches will be a plus.
4. Team player with excellent oral and written communication skills.
5. Self-motivation and critical thinking are essential.

Why consider Novartis?
817 million. That’s how many lives our products touched in 2018. And while we’re proud of that, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are empowered to ask new questions, make bolder decisions and take smarter risks.

We are Novartis. Join us and help reimagine medicine
CNIBR Co. Ltd.
Research & Development
Full Time