Research Associate: Biological Chemistry Group, Oncology

Research Associate: Biological Chemistry Group, Oncology
The Biological Chemistry (BC) group is an early stage drug discovery team within Oncology research at NIBR, focused on understanding and exploiting the molecular mechanisms of novel cancer targets for the discovery, characterization and optimization of small molecule therapeutics. We are seeking a highly motivated, creative and collaborative protein scientist to join our team in a hands-on role to discover the next generation of innovative cancer treatments.

Your Responsibilities:

Your responsibilities include, but are not limited to:
• Development of protein, peptide and nucleic acid tools for the functional and mechanistic characterization of enzymes, substrates, and multi-protein complexes.
• Production and characterization of proteins for use in biochemical and biophysical assays.
• Analysis, interpretation, documentation, and presentation of data to the BC group and multidisciplinary project teams.
• Assessment of emerging technologies with an emphasis on tools and techniques for generating proteins and multiprotein complexes for use in drug discovery.
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.
What you’ll bring to the role:
• BA/BS or MS degree in Molecular biology, Biochemistry, Enzymology, Biochemical engineering or a related field with 2+ years of relevant laboratory experience.
• Hands-on experience with molecular biology techniques such as cloning, site-directed mutagenesis, PCR, gel electrophoresis and western blots.
• Experience with recombinant protein expression and purification using E. coli, baculovirus and/or mammalian cell lines required.
• An interest in understanding protein function, protein-ligand binding interactions, and enzyme mechanisms related to cancer therapeutics.
• Demonstrated ability to analyze, interpret, and present data in a clear manner.

Desirable Requirements:
• Knowledge of FPLC (AKTA) systems and purification with different chromatography methods such as affinity, IEX and SEC is a plus.

Why consider Novartis?
927 million. That’s how many lives our products touched in 2017. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.
Oncology NIBR
Cambridge, MA
Research & Development
Full Time