Senior Investigator, PK Sciences - East Hanover, NJ

Senior Investigator, PK Sciences - East Hanover, NJ
The Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. NIBR includes about 6500 associates across 7 locations worldwide. Translational Medicine (TM) is the clinical research arm of NIBR, and includes about 1000 associates globally. TM plays a pivotal role in bringing innovative medicines to patients, by building on research advances to develop new therapies, and bridging drug discovery and clinical application. PK Sciences (PKS) partners across both NIBR and the Global Drug Development organizations to advance the scientific knowledge of pharmacokinetics, metabolism and clinical pharmacology, and bring it to bear on drug discovery and development challenges throughout R&D.

The Senior Investigator is expected to develop/apply translational PK-PD modeling, PBPK-PD modeling, quantitative & systems pharmacology (QSP) modeling, along with data analysis techniques to facilitate drug discovery, development, and translational research across disease areas.

Key responsibilities will include: (1.) Serves as an expert modeler to provide translational modeling support for global drug development projects; (2.) Acts as a modeling liaison to bridge between the modeling line function and research/development teams from different disease or therapeutic areas; (3.) Performs and oversees biomarker PK / PD analyses using a variety of tools and approaches; (4.) Scripts/writes custom models; (5.) Integrates, interprets and reports data to project teams and other customers; (6.) Drives data-driven modeling at the drug discovery stage across disease areas; (7.) Develops and implements state-of-the-art modeling techniques (such as QSP or virtual human/animal/organ models) to impact drug development projects from discovery to early development; (8.) Demonstrates scientific creativity, collaboration works independently with project teams; (9.) Reviews and advises on translational modeling strategy for discovery programs; (10.) Executes modeling plans, and deliver reports of results
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.
• PhD in pharmacometrics/pharmacology/physiology, biomedical/chemical engineering, or related sciences with hands on experience with modeling tools such as MATLAB, Python, Phoenix, Simcyp, G+, etc. with a minimum of 3-10 years relevant industry experience
• Extensive modeling experience for biological/physiological/phathological/pharmacological systems
• Core competency in mathematics and numerical analysis including ordinary/partial differential equations, numerical optimization, stochastic modeling, etc.
• Exceptional problem-solving skills, learning agility, and collaborative behaviors
• Extensive experience with systems biology/physiology/pharmacology modeling or Virtual Human/Animal/Organ models, PBPK/PD modeling, translational PK-PD modeling, or data analyses
• Broad knowledge of drug discovery and development, e.g., on topics of drug delivery, formulation, ADME, PK/PD or TK/TD, etc.
• Excellent written and oral communication skills
Translational Medicine
East Hanover, NJ
Novartis Pharmaceuticals
Research & Development
Full Time